DLEU2 (deleted in lymphocytic leukemia 2)

2003-02-01  

Identity

HGNC
DLEU2
LOCATION
13q14.2
LOCUSID
8847
ALIAS
ALT1,BCMSUN,DLB2,LEU2,LINC00022,MIR15AHG,NCRNA00022,RFP2,RFP2OS,TRIM13OS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8847
MIM: 605766
HGNC: 13748
Ensembl: ENSG00000231607

Variants:

dbSNP: 8847
ClinVar: 8847
TCGA: ENSG00000231607
COSMIC: DLEU2

RNA/Proteins

Expression (GTEx)

0
1
2
3
4
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
195918242009DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1.64
235930112013Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB.52
204512562010A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample.41
248857942014Hypermethylation and down-regulation of DLEU2 in paediatric acute myeloid leukaemia independent of embedded tumour suppressor miR-15a/16-1.15
239957892014Therapeutic implications of activation of the host gene (Dleu2) promoter for miR-15a/16-1 in chronic lymphocytic leukemia.14
193477352009Chronic lymphocytic leukemia and 13q14: miRs and more.12
296878502018Long non-coding RNA Dleu2 affects proliferation, migration and invasion ability of laryngeal carcinoma cells through triggering miR-16-1 pathway.12
300379802018Role of Circular RNA DLEU2 in Human Acute Myeloid Leukemia.11
308387242019Silencing of DLEU2 suppresses pancreatic cancer cell proliferation and invasion by upregulating microRNA-455.6
289778022017A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway.4

Citation

Dessen P

DLEU2 (deleted in lymphocytic leukemia 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40331/dleu2-(deleted-in-lymphocytic-leukemia-2)