DNAJB4 (DnaJ heat shock protein family (Hsp40) member B4)

2003-08-01  

Identity

HGNC
LOCATION
1p31.1
LOCUSID
ALIAS
DNAJW,DjB4,HLJ1

Other Information

Locus ID:

NCBI: 11080
MIM: 611327
HGNC: 14886
Ensembl: ENSG00000162616

Variants:

dbSNP: 11080
ClinVar: 11080
TCGA: ENSG00000162616
COSMIC: DNAJB4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162616ENST00000370763Q9UDY4
ENSG00000162616ENST00000426517C9JUL4

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
243188772014Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.50
187941312008Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1.45
167881562006A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma.37
157821172005The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion.25
156617472005Low resolution structural study of two human HSP40 chaperones in solution. DJA1 from subfamily A and DJB4 from subfamily B have different quaternary structures.23
201451232010Tumor suppressor HLJ1 binds and functionally alters nucleophosmin via activating enhancer binding protein 2alpha complex formation.14
242935452014DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo.13
297225242018A Targeted Proteomic Approach for Heat Shock Proteins Reveals DNAJB4 as a Suppressor for Melanoma Metastasis.9
233062122013The HLJ1-targeting drug screening identified Chinese herb andrographolide that can suppress tumour growth and invasion in non-small-cell lung cancer.8
213453582011Hepatitis B virus protein up-regulated HLJ1 expression via the transcription factor YY1 in human hepatocarcinoma cells.7

Citation

Dessen P

DNAJB4 (DnaJ heat shock protein family (Hsp40) member B4)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40343/dnajb4-(dnaj-heat-shock-protein-family-(hsp40)-member-b4)