DYNLRB1 (dynein light chain roadblock-type 1)

2003-02-01  

Identity

HGNC
DYNLRB1
LOCATION
20q11.22
LOCUSID
83658
ALIAS
BITH,BLP,DNCL2A,DNLC2A,ROBLD1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83658
MIM: 607167
HGNC: 15468
Ensembl: ENSG00000125971

Variants:

dbSNP: 83658
ClinVar: 83658
TCGA: ENSG00000125971
COSMIC: DYNLRB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125971ENST00000300469Q9NP97
ENSG00000125971ENST00000357156Q9NP97
ENSG00000125971ENST00000374846B1AKR6

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Intraflagellar transportREACTOMER-HSA-5620924

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
233334992013Requirement for protein kinase A in the phosphorylation of the TGFβ receptor-interacting protein km23-1 as a component of TGFβ downstream effects.5
237553072013Decreased tumor progression and invasion by a novel anti-cell motility target for human colorectal carcinoma cells.5
233334992013Requirement for protein kinase A in the phosphorylation of the TGFβ receptor-interacting protein km23-1 as a component of TGFβ downstream effects.5
237553072013Decreased tumor progression and invasion by a novel anti-cell motility target for human colorectal carcinoma cells.5
226375792012The TGFβ receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGFβ1 autoinduction via its association with Ras.12
230796222012Role of km23-1 in RhoA/actin-based cell migration.6
226375792012The TGFβ receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGFβ1 autoinduction via its association with Ras.12
230796222012Role of km23-1 in RhoA/actin-based cell migration.6
195712322009Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier.14
197113522009Requirement of a dynein light chain in TGFbeta/Smad3 signaling.22
195712322009Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier.14
197113522009Requirement of a dynein light chain in TGFbeta/Smad3 signaling.22
180447442008Rab6 family proteins interact with the dynein light chain protein DYNLRB1.38
180447442008Rab6 family proteins interact with the dynein light chain protein DYNLRB1.38
175560762007km23, a transforming growth factor-beta signaling component, is infrequently mutated in human colorectal and gastric cancers.2

Citation

Dessen P

DYNLRB1 (dynein light chain roadblock-type 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40345/dynlrb1-(dynein-light-chain-roadblock-type-1)