Identity
HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
BITH,BLP,DNCL2A,DNLC2A,ROBLD1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 83658
MIM: 607167
HGNC: 15468
Ensembl: ENSG00000125971
Variants:
dbSNP: 83658
ClinVar: 83658
TCGA: ENSG00000125971
COSMIC: DYNLRB1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000125971 | ENST00000300469 | Q9NP97 |
| ENSG00000125971 | ENST00000357156 | Q9NP97 |
| ENSG00000125971 | ENST00000374846 | B1AKR6 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Organelle biogenesis and maintenance | REACTOME | R-HSA-1852241 |
| Cilium Assembly | REACTOME | R-HSA-5617833 |
| Intraflagellar transport | REACTOME | R-HSA-5620924 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 23333499 | 2013 | Requirement for protein kinase A in the phosphorylation of the TGFβ receptor-interacting protein km23-1 as a component of TGFβ downstream effects. | 5 |
| 23755307 | 2013 | Decreased tumor progression and invasion by a novel anti-cell motility target for human colorectal carcinoma cells. | 5 |
| 23333499 | 2013 | Requirement for protein kinase A in the phosphorylation of the TGFβ receptor-interacting protein km23-1 as a component of TGFβ downstream effects. | 5 |
| 23755307 | 2013 | Decreased tumor progression and invasion by a novel anti-cell motility target for human colorectal carcinoma cells. | 5 |
| 22637579 | 2012 | The TGFβ receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGFβ1 autoinduction via its association with Ras. | 12 |
| 23079622 | 2012 | Role of km23-1 in RhoA/actin-based cell migration. | 6 |
| 22637579 | 2012 | The TGFβ receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGFβ1 autoinduction via its association with Ras. | 12 |
| 23079622 | 2012 | Role of km23-1 in RhoA/actin-based cell migration. | 6 |
| 19571232 | 2009 | Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier. | 14 |
| 19711352 | 2009 | Requirement of a dynein light chain in TGFbeta/Smad3 signaling. | 22 |
| 19571232 | 2009 | Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier. | 14 |
| 19711352 | 2009 | Requirement of a dynein light chain in TGFbeta/Smad3 signaling. | 22 |
| 18044744 | 2008 | Rab6 family proteins interact with the dynein light chain protein DYNLRB1. | 38 |
| 18044744 | 2008 | Rab6 family proteins interact with the dynein light chain protein DYNLRB1. | 38 |
| 17556076 | 2007 | km23, a transforming growth factor-beta signaling component, is infrequently mutated in human colorectal and gastric cancers. | 2 |
Citation
Dessen P
DYNLRB1 (dynein light chain roadblock-type 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40345/dynlrb1-(dynein-light-chain-roadblock-type-1)
