FILIP1L (filamin A interacting protein 1 like)

2003-06-01  

Identity

HGNC
FILIP1L
LOCATION
3q12.1
LOCUSID
11259
ALIAS
DOC-1,DOC1,GIP130,GIP90
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11259
MIM: 612993
HGNC: 24589
Ensembl: ENSG00000168386

Variants:

dbSNP: 11259
ClinVar: 11259
TCGA: ENSG00000168386
COSMIC: FILIP1L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168386ENST00000331335Q4L180
ENSG00000168386ENST00000354552Q4L180
ENSG00000168386ENST00000383694Q4L180
ENSG00000168386ENST00000398326Q4L180
ENSG00000168386ENST00000471562Q4L180
ENSG00000168386ENST00000477258H7C4M0
ENSG00000168386ENST00000487087Q4L180
ENSG00000168386ENST00000495625C9JYJ6

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
235121052013Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study.39
206353892011Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.25
243274742014Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis.16
216935942011Downregulation of Filamin A interacting protein 1-like is associated with promoter methylation and induces an invasive phenotype in ovarian cancer.13
217848502011Promotion of heat shock factor Hsf1 degradation via adaptor protein filamin A-interacting protein 1-like (FILIP-1L).12
192700262009Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival.11
159359552005Endothelial monocyte activating polypeptide-II induced gene expression changes in endothelial cells.9
243400502013Down-regulation of Filamin A interacting protein 1-like Is associated with promoter methylation and an invasive phenotype in breast, colon, lung and pancreatic cancers [corrected].7
218320872011Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130).5

Citation

Dessen P

FILIP1L (filamin A interacting protein 1 like)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40353/filip1l-(filamin-a-interacting-protein-1-like)