Identity
HGNC
LOCATION
3p21.2
LOCUSID
ALIAS
MOCA,NEDIDHA,PBP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1795
MIM: 603123
HGNC: 2989
Ensembl: ENSG00000088538
Variants:
dbSNP: 1795
ClinVar: 1795
TCGA: ENSG00000088538
COSMIC: DOCK3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000088538 | ENST00000266037 | Q8IZD9 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Hemostasis | REACTOME | R-HSA-109582 |
| Factors involved in megakaryocyte development and platelet production | REACTOME | R-HSA-983231 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32766788 | 2020 | DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologies. | 9 |
| 32766788 | 2020 | DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologies. | 9 |
| 30976111 | 2019 | Variants in DOCK3 cause developmental delay and hypotonia. | 10 |
| 30976111 | 2019 | Variants in DOCK3 cause developmental delay and hypotonia. | 10 |
| 29130632 | 2018 | DOCK3-related neurodevelopmental syndrome: Biallelic intragenic deletion of DOCK3 in a boy with developmental delay and hypotonia. | 10 |
| 29130632 | 2018 | DOCK3-related neurodevelopmental syndrome: Biallelic intragenic deletion of DOCK3 in a boy with developmental delay and hypotonia. | 10 |
| 28195318 | 2017 | Biallelic loss-of-function variants in DOCK3 cause muscle hypotonia, ataxia, and intellectual disability. | 16 |
| 28195318 | 2017 | Biallelic loss-of-function variants in DOCK3 cause muscle hypotonia, ataxia, and intellectual disability. | 16 |
| 26319681 | 2016 | Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal Models. | 12 |
| 26319681 | 2016 | Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal Models. | 12 |
| 25687035 | 2015 | Inhibition of RAC1-GEF DOCK3 by miR-512-3p contributes to suppression of metastasis in non-small cell lung cancer. | 23 |
| 25687035 | 2015 | Inhibition of RAC1-GEF DOCK3 by miR-512-3p contributes to suppression of metastasis in non-small cell lung cancer. | 23 |
| 22115042 | 2012 | MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins. | 12 |
| 22746061 | 2012 | [Role of Dock3 in axonal regeneration]. | 0 |
| 22115042 | 2012 | MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins. | 12 |
Citation
Dessen P
DOCK3 (dedicator of cytokinesis 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/40355/dock3-(dedicator-of-cytokinesis-3)
