DUSP3 (dual specificity phosphatase 3)

2003-06-01  

Identity

HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
VHR
FUSION GENES

Other Information

Locus ID:

NCBI: 1845
MIM: 600183
HGNC: 3069
Ensembl: ENSG00000108861

Variants:

dbSNP: 1845
ClinVar: 1845
TCGA: ENSG00000108861
COSMIC: DUSP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108861ENST00000226004P51452
ENSG00000108861ENST00000590342K7EPK5
ENSG00000108861ENST00000590753K7ELG5
ENSG00000108861ENST00000590935K7ES89

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
MAP kinase activation in TLR cascadeREACTOMER-HSA-450294
MAPK targets/ Nuclear events mediated by MAP kinasesREACTOMER-HSA-450282
ERK/MAPK targetsREACTOMER-HSA-198753
ERKs are inactivatedREACTOMER-HSA-202670
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Nuclear Events (kinase and transcription factor activation)REACTOMER-HSA-198725

References

Pubmed IDYearTitleCitations
219210272011Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3.40
166040642006Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence.38
124473582003Tyrosine phosphorylation of VHR phosphatase by ZAP-70.24
177857722007Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase.24
185055702008Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR.19
172780982007BRCA1-IRIS activates cyclin D1 expression in breast cancer cells by downregulating the JNK phosphatase DUSP3/VHR.18
190108982008The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer.15
249013442014Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis.12
212629742011Vaccinia H1-related phosphatase is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer.11
300484722018Identification of serum miR-1915-3p and miR-455-3p as biomarkers for breast cancer.11

Citation

Dessen P

DUSP3 (dual specificity phosphatase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40374/dusp3-(dual-specificity-phosphatase-3)