DUSP3 (dual specificity phosphatase 3)

2003-06-01 Affiliation

Identity

HGNC

DUSP3

LOCATION

17q21.31

LOCUSID

1845

ALIAS

VHR

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1845
MIM: 600183
HGNC: 3069
Ensembl: ENSG00000108861

Variants:

dbSNP: 1845
ClinVar: 1845
TCGA: ENSG00000108861
COSMIC: DUSP3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000108861	ENST00000226004	P51452
ENSG00000108861	ENST00000590342	K7EPK5
ENSG00000108861	ENST00000590753	K7ELG5
ENSG00000108861	ENST00000590935	K7ES89

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
MAPK signaling pathway	KEGG	hsa04010
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade	REACTOME	R-HSA-168142
MyD88 cascade initiated on plasma membrane	REACTOME	R-HSA-975871
MAP kinase activation in TLR cascade	REACTOME	R-HSA-450294
MAPK targets/ Nuclear events mediated by MAP kinases	REACTOME	R-HSA-450282
ERK/MAPK targets	REACTOME	R-HSA-198753
ERKs are inactivated	REACTOME	R-HSA-202670
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Toll Like Receptor 5 (TLR5) Cascade	REACTOME	R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	REACTOME	R-HSA-975138
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Nuclear Events (kinase and transcription factor activation)	REACTOME	R-HSA-198725

References

Pubmed ID	Year	Title	Citations
38538536	2024	DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus.	0
38538536	2024	DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus.	0
35899430	2022	The role of dual-specificity phosphatase 3 in melanocytic oncogenesis.	0
35899430	2022	The role of dual-specificity phosphatase 3 in melanocytic oncogenesis.	0
32348128	2020	Allosteric Impact of the Variable Insert Loop in Vaccinia H1-Related (VHR) Phosphatase.	4
32380926	2020	DUSP3 maintains genomic stability and cell proliferation by modulating NER pathway and cell cycle regulatory proteins.	4
32475380	2020	Regulation of signal transducer and activator of transcription 3 activation by dual-specificity phosphatase 3.	4
32348128	2020	Allosteric Impact of the Variable Insert Loop in Vaccinia H1-Related (VHR) Phosphatase.	4
32380926	2020	DUSP3 maintains genomic stability and cell proliferation by modulating NER pathway and cell cycle regulatory proteins.	4
32475380	2020	Regulation of signal transducer and activator of transcription 3 activation by dual-specificity phosphatase 3.	4
30048472	2018	Identification of serum miR-1915-3p and miR-455-3p as biomarkers for breast cancer.	37
30048472	2018	Identification of serum miR-1915-3p and miR-455-3p as biomarkers for breast cancer.	37
28389334	2017	Loss of DUSP3 activity radiosensitizes human tumor cell lines via attenuation of DNA repair pathways.	4
28625849	2017	Leveraging Reciprocity to Identify and Characterize Unknown Allosteric Sites in Protein Tyrosine Phosphatases.	30
28759036	2017	Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration.	14

Citation

Dessen P

DUSP3 (dual specificity phosphatase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40374/js/case-report-explorer/js/lib/hgnc