E2F5 (E2F transcription factor 5)

2003-02-01  

Identity

HGNC
E2F5
LOCATION
8q21.2
LOCUSID
1875
ALIAS
E2F-5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1875
MIM: 600967
HGNC: 3119
Ensembl: ENSG00000133740

Variants:

dbSNP: 1875
ClinVar: 1875
TCGA: ENSG00000133740
COSMIC: E2F5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133740ENST00000256117C9JYE9
ENSG00000133740ENST00000416274Q15329
ENSG00000133740ENST00000418930Q15329
ENSG00000133740ENST00000517476Q15329
ENSG00000133740ENST00000518234H0YBK0
ENSG00000133740ENST00000520225H0YBW8
ENSG00000133740ENST00000521429E5RHD4

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
TGF-beta signaling pathwayKEGGko04350
Cell cycleKEGGhsa04110
TGF-beta signaling pathwayKEGGhsa04350
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionREACTOMER-HSA-2173796
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G0 and Early G1REACTOMER-HSA-1538133
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231

References

Pubmed IDYearTitleCitations
378328052024Expression of CD44 is regulated by ELF3 in 5-FU treated colorectal cancer cells.0
382711392024Knockdown of RNA-binding protein IMP3 suppresses oral squamous cell carcinoma proliferation by destabilizing E2F5 transcript.0
378328052024Expression of CD44 is regulated by ELF3 in 5-FU treated colorectal cancer cells.0
382711392024Knockdown of RNA-binding protein IMP3 suppresses oral squamous cell carcinoma proliferation by destabilizing E2F5 transcript.0
375679062023Transcriptional induction of NF-κB-inducing kinase by E2F4/5 facilitates collective invasion of GBM cells.2
375679062023Transcriptional induction of NF-κB-inducing kinase by E2F4/5 facilitates collective invasion of GBM cells.2
345839052022E2F5 promotes proliferation and invasion of gastric cancer through directly upregulating UBE2T transcription.8
359854392022METTL3 promotes the growth and metastasis of pancreatic cancer by regulating the m6A modification and stability of E2F5.4
345839052022E2F5 promotes proliferation and invasion of gastric cancer through directly upregulating UBE2T transcription.8
359854392022METTL3 promotes the growth and metastasis of pancreatic cancer by regulating the m6A modification and stability of E2F5.4
333901862021CDK13 upregulation-induced formation of the positive feedback loop among circCDK13, miR-212-5p/miR-449a and E2F5 contributes to prostate carcinogenesis.24
337348942021E2F5 Promotes the Malignancy of Ovarian Cancer Via the Regulation of Hippo and Wnt Pathways.3
337887232021Targeting CALM2 Inhibits Hepatocellular Carcinoma Growth and Metastasis by Suppressing E2F5-mediated Cell Cycle Progression.4
333901862021CDK13 upregulation-induced formation of the positive feedback loop among circCDK13, miR-212-5p/miR-449a and E2F5 contributes to prostate carcinogenesis.24
337348942021E2F5 Promotes the Malignancy of Ovarian Cancer Via the Regulation of Hippo and Wnt Pathways.3

Citation

Dessen P

E2F5 (E2F transcription factor 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40386/js/css/humanGenome