E4F1 (E4F transcription factor 1)

2003-02-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
E4F
FUSION GENES

Other Information

Locus ID:

NCBI: 1877
MIM: 603022
HGNC: 3121
Ensembl: ENSG00000167967

Variants:

dbSNP: 1877
ClinVar: 1877
TCGA: ENSG00000167967
COSMIC: E4F1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167967ENST00000301727Q66K89
ENSG00000167967ENST00000562589H3BQZ4
ENSG00000167967ENST00000564139H3BUJ7
ENSG00000167967ENST00000565090H3BSL4
ENSG00000167967ENST00000565413H3BN24

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
171103362006E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.77
269688972016New genes and pathomechanisms in mitochondrial disorders unraveled by NGS technologies.31
175571142007The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.22
147296132004Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene.20
166521572006The LIM-only protein FHL2 is a negative regulator of E4F1.16
124467182003Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition.13
217089272011E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.8
241634012014Downregulation of transcription factor E4F1 in hepatocarcinoma cells: HBV-dependent effects on autophagy, proliferation and metabolism.4
155794452004E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis.3
305066472019E4F1 silencing inhibits the cell growth through cell-cycle arrest in malignant transformed cells induced by hydroquinone.0

Citation

Dessen P

E4F1 (E4F transcription factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40389/e4f1-(e4f-transcription-factor-1)