EFNA2 (ephrin A2)

2003-08-01 Affiliation

Identity

HGNC

EFNA2

LOCATION

19p13.3

LOCUSID

1943

ALIAS

ELF-1,EPLG6,HEK7-L,LERK-6,LERK6

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1943
MIM: 602756
HGNC: 3222
Ensembl: ENSG00000099617

Variants:

dbSNP: 1943
ClinVar: 1943
TCGA: ENSG00000099617
COSMIC: EFNA2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000099617	ENST00000215368	O43921

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Axon guidance	KEGG	hsa04360
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Ras signaling pathway	KEGG	hsa04014
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
EPH-Ephrin signaling	REACTOME	R-HSA-2682334
EPHA-mediated growth cone collapse	REACTOME	R-HSA-3928663
EPH-ephrin mediated repulsion of cells	REACTOME	R-HSA-3928665

References

Pubmed ID	Year	Title	Citations
19525919	2009	Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.	52
22247258	2012	EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis.	35
12421992	2002	Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus.	18
24550731	2014	CIB1 synergizes with EphrinA2 to regulate Kaposi's sarcoma-associated herpesvirus macropinocytic entry in human microvascular dermal endothelial cells.	16
11884456	2002	Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain.	15
16158060	2005	Inactivation of ELF/TGF-beta signaling in human gastrointestinal cancer.	13
11860487	2001	Expression of ephrin-A2 in the superior colliculus and EphA5 in the retina following optic nerve section in adult rat.	10
17878388	2007	Elf-1 binds to GGAA elements on the FcRgamma promoter and represses its expression.	6
24050852	2013	The prognostic role of ephrin A2 and endothelial growth factor receptor pathway mediators in patients with advanced colorectal cancer treated with cetuximab.	6
26561474	2016	Diagnostic and prognostic value of tissue and circulating levels of Ephrin-A2 in prostate cancer.	1

Citation

Dessen P

EFNA2 (ephrin A2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40413/efna2-(ephrin-a2)