EFNB1 (ephrin B1)

2003-11-01  

Identity

HGNC
LOCATION
Xq13.1
LOCUSID
ALIAS
CFND,CFNS,EFB1,EFL3,EPLG2,Elk-L,LERK2
FUSION GENES

Other Information

Locus ID:

NCBI: 1947
MIM: 300035
HGNC: 3226
Ensembl: ENSG00000090776

Variants:

dbSNP: 1947
ClinVar: 1947
TCGA: ENSG00000090776
COSMIC: EFNB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090776ENST00000204961P98172

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Ephrin signalingREACTOMER-HSA-3928664
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
179066252007EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells.102
129196742003Control of skeletal patterning by ephrinB1-EphB interactions.84
206437272010Prevalence and complications of single-gene and chromosomal disorders in craniosynostosis.62
151241022004Mutations of the ephrin-B1 gene cause craniofrontonasal syndrome.57
123844302002Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells.54
120848152002Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.34
196722982009A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells.31
203083252010Ephrin-B1 reverse signaling controls a posttranscriptional feedback mechanism via miR-124.29
122234692002EphB1 associates with Grb7 and regulates cell migration.26
124759482002Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells.25

Citation

Dessen P

EFNB1 (ephrin B1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40415/efnb1-(ephrin-b1)