EI24 (EI24 autophagy associated transmembrane protein)

2003-02-01 Affiliation

Identity

HGNC

EI24

LOCATION

11q24.2

LOCUSID

9538

ALIAS

EPG4,PIG8,TP53I8

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9538
MIM: 605170
HGNC: 13276
Ensembl: ENSG00000149547

Variants:

dbSNP: 9538
ClinVar: 9538
TCGA: ENSG00000149547
COSMIC: EI24

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000149547	ENST00000278903	O14681
ENSG00000149547	ENST00000278903	A0A024R3I8
ENSG00000149547	ENST00000524723	E9PS58
ENSG00000149547	ENST00000527131	E9PL33
ENSG00000149547	ENST00000527235	E9PK61
ENSG00000149547	ENST00000527520	E9PLB8
ENSG00000149547	ENST00000527842	E9PM05
ENSG00000149547	ENST00000529812	E9PQN7
ENSG00000149547	ENST00000531636	A0A087WV44
ENSG00000149547	ENST00000534546	O14681
ENSG00000149547	ENST00000615917	B7ZB74
ENSG00000149547	ENST00000618552	B7ZB74
ENSG00000149547	ENST00000620753	O14681
ENSG00000149547	ENST00000620753	A0A024R3I8

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
p53 signaling pathway	KEGG	ko04115
p53 signaling pathway	KEGG	hsa04115

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
28038450	2017	MicroRNA-455-3p promotes invasion and migration in triple negative breast cancer by targeting tumor suppressor EI24.	19
17981155	2007	Loss of putative tumor suppressor EI24/PIG8 confers resistance to etoposide.	14
21154811	2011	Inactivation of CHEK1 and EI24 is associated with the development of invasive cervical carcinoma: clinical and prognostic implications.	12
24280371	2013	EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity.	10
27541728	2016	Functional characterization of EI24-induced autophagy in the degradation of RING-domain E3 ligases.	10
24821838	2014	The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain.	9
21803008	2011	Frequent alterations of LOH11CR2A, PIG8 and CHEK1 genes at chromosomal 11q24.1-24.2 region in breast carcinoma: clinical and prognostic implications.	8
24014029	2013	Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation.	5
26342551	2015	Reduced expression of EI24 confers resistance to gefitinib through IGF-1R signaling in PC9 NSCLC cells.	2
30784913	2019	Integrated analysis of the prognostic value of TP53 dependent etoposide-induced gene 24 in non-small cell lung cancer.	0

Citation

Dessen P

EI24 (EI24 autophagy associated transmembrane protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40422/ei24-(ei24-autophagy-associated-transmembrane-protein)