EIF3H (eukaryotic translation initiation factor 3 subunit H)

2003-02-01  

Identity

HGNC
EIF3H
LOCATION
8q23.3
LOCUSID
8667
ALIAS
EIF3S3,eIF3-gamma,eIF3-p40
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8667
MIM: 603912
HGNC: 3273
Ensembl: ENSG00000147677

Variants:

dbSNP: 8667
ClinVar: 8667
TCGA: ENSG00000147677
COSMIC: EIF3H

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147677ENST00000276682B3KS98
ENSG00000147677ENST00000518949E5RJT0
ENSG00000147677ENST00000518995E5RGU4
ENSG00000147677ENST00000519046E5RHC7
ENSG00000147677ENST00000520813E5RFW7
ENSG00000147677ENST00000521861O15372
ENSG00000147677ENST00000521861Q6IB98
ENSG00000147677ENST00000522453E5RFH0
ENSG00000147677ENST00000522800E5RH59
ENSG00000147677ENST00000611080A0A087WZK9

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complexREACTOMER-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385146062024The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression.0
385146062024The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression.0
375276602023Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer.7
375590972023The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis.2
375276602023Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer.7
375590972023The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis.2
363500082022EIF3H stabilizes CCND1 to promotes intrahepatic cholangiocarcinoma progression via Wnt/β-catenin signaling.3
363500082022EIF3H stabilizes CCND1 to promotes intrahepatic cholangiocarcinoma progression via Wnt/β-catenin signaling.3
335082742021EIF3H knockdown inhibits malignant melanoma through regulating cell proliferation, apoptosis and cell cycle.2
340380612021The effect of miR-496 on eIF3h in lung invasive adenocarcinoma.1
335082742021EIF3H knockdown inhibits malignant melanoma through regulating cell proliferation, apoptosis and cell cycle.2
340380612021The effect of miR-496 on eIF3h in lung invasive adenocarcinoma.1
322690442020EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control of YAP Stability.18
328678212020EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability.25
322690442020EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control of YAP Stability.18

Citation

Dessen P

EIF3H (eukaryotic translation initiation factor 3 subunit H)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40427/eif3h-(eukaryotic-translation-initiation-factor-3-subunit-h)