EIF3E (eukaryotic translation initiation factor 3 subunit E)

2003-02-01  

Identity

HGNC
EIF3E
LOCATION
8q23.1
LOCUSID
3646
ALIAS
EIF3-P48,EIF3S6,INT6,eIF3-p46
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3646
MIM: 602210
HGNC: 3277
Ensembl: ENSG00000104408

Variants:

dbSNP: 3646
ClinVar: 3646
TCGA: ENSG00000104408
COSMIC: EIF3E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104408ENST00000220849P60228
ENSG00000104408ENST00000518100E5RIP5
ENSG00000104408ENST00000518345E5RIT4
ENSG00000104408ENST00000519030E5RGA2
ENSG00000104408ENST00000519627E5RHS5
ENSG00000104408ENST00000521297H0YBP5
ENSG00000104408ENST00000521440H0YBR5
ENSG00000104408ENST00000522352H0YAW4
ENSG00000104408ENST00000522445E5RII3
ENSG00000104408ENST00000522887E5RJ25

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complexREACTOMER-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
167665232006Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.74
240927552013Human eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome.48
225533362012The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1.42
122206262002Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome.27
204538792010An oncogenic role of eIF3e/INT6 in human breast cancer.27
174687412007Human INT6/eIF3e is required for nonsense-mediated mRNA decay.26
158672132005Int6 expression can predict survival in early-stage non-small cell lung cancer patients.19
274772752016A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism.19
155580172005Silencing of human Int-6 impairs mitosis progression and inhibits cyclin B-Cdk1 activation.16
247368432014Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e.14

Citation

Dessen P

EIF3E (eukaryotic translation initiation factor 3 subunit E)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40428/eif3e-(eukaryotic-translation-initiation-factor-3-subunit-e)