EIF3B (eukaryotic translation initiation factor 3 subunit B)

2003-02-01  

Identity

HGNC
LOCATION
7p22.3
LOCUSID
ALIAS
EIF3-ETA,EIF3-P110,EIF3-P116,EIF3S9,PRT1
FUSION GENES

Other Information

Locus ID:

NCBI: 8662
MIM: 603917
HGNC: 3280
Ensembl: ENSG00000106263

Variants:

dbSNP: 8662
ClinVar: 8662
TCGA: ENSG00000106263
COSMIC: EIF3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106263ENST00000360876P55884
ENSG00000106263ENST00000360876A0A024R821
ENSG00000106263ENST00000397011P55884
ENSG00000106263ENST00000397011A0A024R821
ENSG00000106263ENST00000413917C9JZG1
ENSG00000106263ENST00000431643C9JQN7

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complexREACTOMER-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
386875092024EIF3B stabilizes PCNA by counteracting SYVN1-mediated ubiquitination to serve as a promotor in cholangiocarcinoma.0
386875092024EIF3B stabilizes PCNA by counteracting SYVN1-mediated ubiquitination to serve as a promotor in cholangiocarcinoma.0
350403742022Eukaryotic translation initiation factor 3 subunit B could serve as a potential prognostic predictor for breast cancer.2
360506012022EIF3B stabilizes PTGS2 expression by counteracting MDM2-mediated ubiquitination to promote the development and progression of malignant melanoma.2
350403742022Eukaryotic translation initiation factor 3 subunit B could serve as a potential prognostic predictor for breast cancer.2
360506012022EIF3B stabilizes PTGS2 expression by counteracting MDM2-mediated ubiquitination to promote the development and progression of malignant melanoma.2
346178512021EIF3B Associates with Exacerbated Clinical Features, Poor Treatment Response and Survival in Adult Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Patients.1
346178512021EIF3B Associates with Exacerbated Clinical Features, Poor Treatment Response and Survival in Adult Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Patients.1
325569982020Eukaryotic translation initiation factor 3 subunit b is a novel oncogenic factor in prostate cancer.5
325569982020Eukaryotic translation initiation factor 3 subunit b is a novel oncogenic factor in prostate cancer.5
305515372019Effects of EIF3B gene downregulation on apoptosis and proliferation of human ovarian cancer SKOV3 and HO-8910 cells.10
313225392019Eukaryotic translation initiation factor 3B is overexpressed and correlates with deteriorated tumor features and unfavorable survival profiles in cervical cancer patients.3
314230122019Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer.16
305515372019Effects of EIF3B gene downregulation on apoptosis and proliferation of human ovarian cancer SKOV3 and HO-8910 cells.10
313225392019Eukaryotic translation initiation factor 3B is overexpressed and correlates with deteriorated tumor features and unfavorable survival profiles in cervical cancer patients.3

Citation

Dessen P

EIF3B (eukaryotic translation initiation factor 3 subunit B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40430/eif3b-(eukaryotic-translation-initiation-factor-3-subunit-b)