EIF4G1 (eukaryotic translation initiation factor 4 gamma 1)

2003-02-01

Identity

HGNC

EIF4G1

LOCATION

3q27.1

LOCUSID

1981

ALIAS

EIF-4G1,EIF4F,EIF4G,EIF4GI,P220,PARK18

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1981
MIM: 600495
HGNC: 3296
Ensembl: ENSG00000114867

Variants:

dbSNP: 1981
ClinVar: 1981
TCGA: ENSG00000114867
COSMIC: EIF4G1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000114867	ENST00000342981	Q04637
ENSG00000114867	ENST00000346169	Q04637
ENSG00000114867	ENST00000350481	Q04637
ENSG00000114867	ENST00000352767	Q04637
ENSG00000114867	ENST00000382330	Q04637
ENSG00000114867	ENST00000392537	Q04637
ENSG00000114867	ENST00000411531	E7EUU4
ENSG00000114867	ENST00000413967	F8WB97
ENSG00000114867	ENST00000414031	Q04637
ENSG00000114867	ENST00000421110	C9K073

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Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	REACTOME	R-HSA-72662
Antiviral mechanism by IFN-stimulated genes	REACTOME	R-HSA-1169410
AUF1 (hnRNP D0) binds and destabilizes mRNA	REACTOME	R-HSA-450408
Cap-dependent Translation Initiation	REACTOME	R-HSA-72737
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Deadenylation of mRNA	REACTOME	R-HSA-429947
Deadenylation-dependent mRNA decay	REACTOME	R-HSA-429914
eIF4F complex	KEGG	hsa_M00428
eIF4F complex	KEGG	M00428
Eukaryotic Translation Initiation	REACTOME	R-HSA-72613

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
33239198	2021	Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease.	11
35163752	2022	Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1147 Is Specific for eIF4G1 Bound to eIF4E in Delayed Neuronal Death after Ischemia.	0
35163752	2022	Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1147 Is Specific for eIF4G1 Bound to eIF4E in Delayed Neuronal Death after Ischemia.	0
35857873	2022	Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation.	6
35857873	2022	Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation.	6
36551184	2022	EIF4G1 Is a Potential Prognostic Biomarker of Breast Cancer.	2
36551184	2022	EIF4G1 Is a Potential Prognostic Biomarker of Breast Cancer.	2
36897548	2023	Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma.	1
36897548	2023	Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma.	1
37132650	2023	Thermodynamically Favorable Interactions between eIF4E Binding Domain of eIF4GI with Structured 5'-Untranslated Regions Drive Cap-Independent Translation of Selected mRNAs.	1

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Citation

Dessen P

EIF4G1 (eukaryotic translation initiation factor 4 gamma 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40433