ELF3 (E74 like ETS transcription factor 3)

2003-02-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
EPR-1,ERT,ESE-1,ESX
FUSION GENES

Other Information

Locus ID:

NCBI: 1999
MIM: 602191
HGNC: 3318
Ensembl: ENSG00000163435

Variants:

dbSNP: 1999
ClinVar: 1999
TCGA: ENSG00000163435
COSMIC: ELF3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163435ENST00000359651P78545
ENSG00000163435ENST00000359651A0A024R974
ENSG00000163435ENST00000367283P78545
ENSG00000163435ENST00000367283A0A024R974
ENSG00000163435ENST00000367284P78545
ENSG00000163435ENST00000367284A0A024R974
ENSG00000163435ENST00000446188Q5SR36

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
221586142012E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress.30
184752892008Regulation of epithelium-specific Ets-like factors ESE-1 and ESE-3 in airway epithelial cells: potential roles in airway inflammation.29
268049192016Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation.29
190748492008ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells.28
180447102008ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes.25
147674722004ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells.24
236873372013ETS transcription factor ESE1/ELF3 orchestrates a positive feedback loop that constitutively activates NF-κB and drives prostate cancer progression.24
151699142004The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism.23
281999762017ELF3 is a negative regulator of epithelial-mesenchymal transition in ovarian cancer cells.22
295237812018ELF3 promotes epithelial-mesenchymal transition by protecting ZEB1 from miR-141-3p-mediated silencing in hepatocellular carcinoma.22

Citation

Dessen P

ELF3 (E74 like ETS transcription factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40439/elf3-(e74-like-ets-transcription-factor-3)