ELK4 (ETS transcription factor ELK4)

2003-02-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
SAP1
FUSION GENES

Other Information

Locus ID:

NCBI: 2005
MIM: 600246
HGNC: 3326
Ensembl: ENSG00000158711

Variants:

dbSNP: 2005
ClinVar: 2005
TCGA: ENSG00000158711
COSMIC: ELK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158711ENST00000289703P28324
ENSG00000158711ENST00000289703A0A024R997
ENSG00000158711ENST00000357992P28324
ENSG00000158711ENST00000357992A0A024R9C2
ENSG00000158711ENST00000468523A0A087X2F7
ENSG00000158711ENST00000616704P28324
ENSG00000158711ENST00000616704A0A024R9C2

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375190062023ELK4 Promotes Cell Cycle Progression and Stem Cell-like Characteristics in HPV-associated Cervical Cancer by Regulating the FBXO22/PTEN Axis.0
377775422023IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia.1
375190062023ELK4 Promotes Cell Cycle Progression and Stem Cell-like Characteristics in HPV-associated Cervical Cancer by Regulating the FBXO22/PTEN Axis.0
377775422023IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia.1
343728822021ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis.16
346637882021ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis.13
343728822021ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis.16
346637882021ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis.13
323727072020TRA2A-induced upregulation of LINC00662 regulates blood-brain barrier permeability by affecting ELK4 mRNA stability in Alzheimer's microenvironment.14
323727072020TRA2A-induced upregulation of LINC00662 regulates blood-brain barrier permeability by affecting ELK4 mRNA stability in Alzheimer's microenvironment.14
286557582017Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.31
286557582017Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.31
260280362016Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway.31
269388742016Role of CTCF in Regulating SLC45A3-ELK4 Chimeric RNA.15
260280362016Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway.31

Citation

Dessen P

ELK4 (ETS transcription factor ELK4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40444