EPHA4 (EPH receptor A4)

2003-11-01 Affiliation

Identity

HGNC

EPHA4

LOCATION

2q36.1

LOCUSID

2043

ALIAS

EK8,HEK8,SEK,TYRO1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2043
MIM: 602188
HGNC: 3388
Ensembl: ENSG00000116106

Variants:

dbSNP: 2043
ClinVar: 2043
TCGA: ENSG00000116106
COSMIC: EPHA4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000116106	ENST00000281821	P54764
ENSG00000116106	ENST00000281821	A0A024R452
ENSG00000116106	ENST00000409854	E9PG71
ENSG00000116106	ENST00000409938	P54764
ENSG00000116106	ENST00000409938	A0A024R452
ENSG00000116106	ENST00000415749	F8WBU0
ENSG00000116106	ENST00000419964	C9JEM6
ENSG00000116106	ENST00000424339	H7C2W7
ENSG00000116106	ENST00000434266	C9JIX8
ENSG00000116106	ENST00000441679	H7C1N8
ENSG00000116106	ENST00000443796	C9JFX5
ENSG00000116106	ENST00000541600	F5GZZ5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Axon guidance	KEGG	hsa04360
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
EPH-Ephrin signaling	REACTOME	R-HSA-2682334
EPHA-mediated growth cone collapse	REACTOME	R-HSA-3928663
EPH-ephrin mediated repulsion of cells	REACTOME	R-HSA-3928665

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20100581	2010	Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort.	169
22922411	2012	EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans.	100
21935409	2011	Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.	49
15994237	2005	Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets.	48
18790757	2008	EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line.	46
15313894	2004	Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sézary syndrome identified by gene expression analysis.	45
16365308	2005	Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains.	43
12084815	2002	Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.	34
18695888	2008	Overexpression of EphA4 gene and reduced expression of EphB2 gene correlates with liver metastasis in colorectal cancer.	27
16965393	2006	EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth.	22

Citation

Dessen P

EPHA4 (EPH receptor A4)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40464/epha4-(eph-receptor-a4)