EPHA5 (EPH receptor A5)

2003-02-01 Affiliation

Identity

HGNC

EPHA5

LOCATION

4q13.1

LOCUSID

2044

ALIAS

CEK7,EHK-1,EHK1,EK7,HEK7,TYRO4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2044
MIM: 600004
HGNC: 3389
Ensembl: ENSG00000145242

Variants:

dbSNP: 2044
ClinVar: 2044
TCGA: ENSG00000145242
COSMIC: EPHA5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000145242	ENST00000273854	P54756
ENSG00000145242	ENST00000273854	A0A384MU00
ENSG00000145242	ENST00000354839	P54756
ENSG00000145242	ENST00000432638	F8W9W0
ENSG00000145242	ENST00000511294	F8VP57
ENSG00000145242	ENST00000613740	B7ZKW7
ENSG00000145242	ENST00000622150	B7ZKJ3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Axon guidance	KEGG	hsa04360
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
EPH-Ephrin signaling	REACTOME	R-HSA-2682334
EPHA-mediated growth cone collapse	REACTOME	R-HSA-3928663
EPH-ephrin mediated repulsion of cells	REACTOME	R-HSA-3928665

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation	associated	PD	22843789, 26133776, 26133777, 26763541
PA445204	Ovarian Neoplasms	Disease	ClinicalAnnotation	associated	PD	22843789, 26133776, 26133777, 26763541
PA450761	paclitaxel	Chemical	ClinicalAnnotation	associated	PD	22843789, 26133776, 26133777, 26763541

References

Pubmed ID	Year	Title	Citations
35332588	2022	Expression of EPHA5 in lung adenocarcinoma is associated with lymph node metastasis and EGFR mutation.	2
36164608	2022	Association between EPHA5 methylation status in peripheral blood leukocytes and the risk and prognosis of gastric cancer.	1
36345952	2022	Immunohistochemical evaluation of forkhead box A1 and EphA5 markers in serous ovarian carcinomas, and their impact on the clinical outcome of patients.	1
35332588	2022	Expression of EPHA5 in lung adenocarcinoma is associated with lymph node metastasis and EGFR mutation.	2
36164608	2022	Association between EPHA5 methylation status in peripheral blood leukocytes and the risk and prognosis of gastric cancer.	1
36345952	2022	Immunohistochemical evaluation of forkhead box A1 and EphA5 markers in serous ovarian carcinomas, and their impact on the clinical outcome of patients.	1
34109382	2021	Deep learning model reveals potential risk genes for ADHD, especially Ephrin receptor gene EPHA5.	5
34109382	2021	Deep learning model reveals potential risk genes for ADHD, especially Ephrin receptor gene EPHA5.	5
31823378	2020	Genetic variation in EPHA contributes to sensitivity to paclitaxel-induced peripheral neuropathy.	9
32234341	2020	EPHA5 mutation impairs natural killer cell-mediated cytotoxicity against non-small lung cancer cells and promotes cancer cell migration and invasion.	6
33288738	2020	EPHA5 mutations predict survival after immunotherapy in lung adenocarcinoma.	12
31823378	2020	Genetic variation in EPHA contributes to sensitivity to paclitaxel-induced peripheral neuropathy.	9
32234341	2020	EPHA5 mutation impairs natural killer cell-mediated cytotoxicity against non-small lung cancer cells and promotes cancer cell migration and invasion.	6
33288738	2020	EPHA5 mutations predict survival after immunotherapy in lung adenocarcinoma.	12
27582484	2017	Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.	9

Citation

Dessen P

EPHA5 (EPH receptor A5)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40465/epha5-(eph-receptor-a5)