LIMA1 (LIM domain and actin binding 1)

2003-02-01  

Identity

HGNC
LOCATION
12q13.12
LOCUSID
ALIAS
EPLIN,LDLCQ8,SREBP3
FUSION GENES

Other Information

Locus ID:

NCBI: 51474
MIM: 608364
HGNC: 24636
Ensembl: ENSG00000050405

Variants:

dbSNP: 51474
ClinVar: 51474
TCGA: ENSG00000050405
COSMIC: LIMA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000050405ENST00000341247Q9UHB6
ENSG00000050405ENST00000394943Q9UHB6
ENSG00000050405ENST00000547825Q9UHB6
ENSG00000050405ENST00000550592F8VVQ7
ENSG00000050405ENST00000551691F8VTU2
ENSG00000050405ENST00000552491F8VS07
ENSG00000050405ENST00000552720F8VRN8
ENSG00000050405ENST00000552783Q9UHB6
ENSG00000050405ENST00000552823Q9UHB6
ENSG00000050405ENST00000552909F8VQE1

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180939412008EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.142
187961372008Eplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome.24
241352822013DNp73 exerts function in metastasis initiation by disconnecting the inhibitory role of EPLIN on IGF1R-AKT/STAT3 signaling.24
221946092012Epithelial protein lost in neoplasm (EPLIN) interacts with α-catenin and actin filaments in endothelial cells and stabilizes vascular capillary network in vitro.20
216252162011EPLIN downregulation promotes epithelial-mesenchymal transition in prostate cancer cells and correlates with clinical lymph node metastasis.19
192214762009The actin-binding and bundling protein, EPLIN, is required for cytokinesis.15
231888292013Epidermal growth factor promotes protein degradation of epithelial protein lost in neoplasm (EPLIN), a putative metastasis suppressor, during epithelial-mesenchymal transition.13
208481802010The impact of EPLINα (Epithelial protein lost in neoplasm) on endothelial cells, angiogenesis and tumorigenesis.7
263508862015EPLIN: a fundamental actin regulator in cancer metastasis?6
284654382017Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm.5

Citation

Dessen P

LIMA1 (LIM domain and actin binding 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40474/lima1-(lim-domain-and-actin-binding-1)