DCBLD2 (discoidin, CUB and LCCL domain containing 2)

2003-02-01  

Identity

HGNC
DCBLD2
LOCATION
3q12.1
LOCUSID
131566
ALIAS
CLCP1,ESDN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 131566
MIM: 608698
HGNC: 24627
Ensembl: ENSG00000057019

Variants:

dbSNP: 131566
ClinVar: 131566
TCGA: ENSG00000057019
COSMIC: DCBLD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000057019ENST00000326840Q96PD2
ENSG00000057019ENST00000326857Q96PD2
ENSG00000057019ENST00000449482C9JIW6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
250618742014EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis.32
241774222013Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis.19
183144832008Epigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion.13
196960272009Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination.10
175705162007Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells.7
176972602007ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis.7
237700912013Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL.5
290259732017Dynamic multi-site phosphorylation by Fyn and Abl drives the interaction between CRKL and the novel scaffolding receptors DCBLD1 and DCBLD2.4
309028982019The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease.4

Citation

Dessen P

DCBLD2 (discoidin, CUB and LCCL domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40498/dcbld2-(discoidin-cub-and-lccl-domain-containing-2)