Identity
HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
EV1,EVER1,EVIN1,LAK-4P,TNRC6C-AS1,lnc
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11322
MIM: 605828
HGNC: 18021
Ensembl: ENSG00000141524
Variants:
dbSNP: 11322
ClinVar: 11322
TCGA: ENSG00000141524
COSMIC: TMC6
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Neutrophil degranulation | REACTOME | R-HSA-6798695 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32917726 | 2020 | Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components. | 4 |
| 32917726 | 2020 | Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components. | 4 |
| 29893424 | 2018 | LncRNA TNRC6C-AS1 regulates UNC5B in thyroid cancer to influence cell proliferation, migration, and invasion as a competing endogenous RNA of miR-129-5p. | 18 |
| 30068544 | 2018 | The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses. | 60 |
| 29893424 | 2018 | LncRNA TNRC6C-AS1 regulates UNC5B in thyroid cancer to influence cell proliferation, migration, and invasion as a competing endogenous RNA of miR-129-5p. | 18 |
| 30068544 | 2018 | The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses. | 60 |
| 27097911 | 2016 | Variants of EVER1 and EVER2 (TMC6 and TMC8) and human papillomavirus status in patients with mucosal squamous cell carcinoma of the head and neck. | 9 |
| 27899077 | 2016 | Genetic polymorphisms of FAS and EVER genes in a Greek population and their susceptibility to cervical cancer: a case control study. | 3 |
| 27097911 | 2016 | Variants of EVER1 and EVER2 (TMC6 and TMC8) and human papillomavirus status in patients with mucosal squamous cell carcinoma of the head and neck. | 9 |
| 27899077 | 2016 | Genetic polymorphisms of FAS and EVER genes in a Greek population and their susceptibility to cervical cancer: a case control study. | 3 |
| 23534907 | 2015 | Epidermodysplasia verruciformis in lipoid proteinosis: case report and discussion of pathophysiology. | 1 |
| 25378492 | 2015 | Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus. | 2 |
| 26047157 | 2015 | Exome Sequencing of Phenotypic Extremes Identifies CAV2 and TMC6 as Interacting Modifiers of Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis. | 21 |
| 26126409 | 2015 | Genetic variations in the epidermodysplasia verruciformis (EVER/TMC) genes, cutaneous human papillomavirus infection and squamous cell carcinoma of the skin. | 2 |
| 26227733 | 2015 | Risk of Cutaneous Squamous Cell Carcinoma Development in Renal Transplant Recipients Is Independent of TMC/EVER Alterations. | 2 |
Citation
Dessen P
TMC6 (transmembrane channel like 6)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40507/tmc6-(transmembrane-channel-like-6)
