Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2147
MIM: 176930
HGNC: 3535
Ensembl: ENSG00000180210
Variants:
dbSNP: 2147
ClinVar: 2147
TCGA: ENSG00000180210
COSMIC: F2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000180210 | ENST00000311907 | P00734 |
| ENSG00000180210 | ENST00000442468 | C9JV37 |
| ENSG00000180210 | ENST00000530231 | E9PIT3 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166179849 | avatrombopag | Chemical | LabelAnnotation | associated | |||
| PA166182748 | lusutrombopag | Chemical | LabelAnnotation | associated | |||
| PA27946 | F2R | Gene | Pathway | associated | 20938371 | ||
| PA27949 | F2RL3 | Gene | Pathway | associated | 20938371 | ||
| PA28660 | GGCX | Gene | Pathway | associated | |||
| PA446969 | Venous Thrombosis | Disease | ClinicalAnnotation | associated | PD | 12069454, 15208046, 16769590, 28750087 | |
| PA447054 | Stroke | Disease | ClinicalAnnotation | associated | PD | 12069454, 15208046, 16769590, 28750087 | |
| PA451581 | tamoxifen | Chemical | LabelAnnotation | associated | |||
| PA452637 | hormonal contraceptives for systemic use | Chemical | ClinicalAnnotation | associated | PD | 12069454, 15208046, 16769590, 28750087 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37918971 | 2024 | Effect of prothrombin Belgrade mutation, causing antithrombin resistance, on fibrin clot properties. | 1 |
| 37984359 | 2024 | The Complex Role of Thrombin in Cancer and Metastasis: Focus on Interactions with the Immune System. | 1 |
| 38164089 | 2024 | Thrombin Priming Promotes the Neuroprotective Effects of Human Wharton's Jelly-Derived Mesenchymal Stem Cells Via the HGF/AKT/STAT3 Signaling Pathway. | 0 |
| 38174561 | 2024 | Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin. | 1 |
| 38397467 | 2024 | Comprehensive Analysis of the Role of Fibrinogen and Thrombin in Clot Formation and Structure for Plasma and Purified Fibrinogen. | 1 |
| 37918971 | 2024 | Effect of prothrombin Belgrade mutation, causing antithrombin resistance, on fibrin clot properties. | 1 |
| 37984359 | 2024 | The Complex Role of Thrombin in Cancer and Metastasis: Focus on Interactions with the Immune System. | 1 |
| 38164089 | 2024 | Thrombin Priming Promotes the Neuroprotective Effects of Human Wharton's Jelly-Derived Mesenchymal Stem Cells Via the HGF/AKT/STAT3 Signaling Pathway. | 0 |
| 38174561 | 2024 | Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin. | 1 |
| 38397467 | 2024 | Comprehensive Analysis of the Role of Fibrinogen and Thrombin in Clot Formation and Structure for Plasma and Purified Fibrinogen. | 1 |
| 36724509 | 2023 | Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation. | 0 |
| 36758726 | 2023 | Intraindividual variability over time of thrombin generation in patients with cirrhosis. | 1 |
| 37044132 | 2023 | Low α-Thrombin/GPIbα Interaction Is a Potential Contributor to Platelet Hyper-reactivity in COVID-19 Patients. | 1 |
| 37046189 | 2023 | Integrative analysis of HASMCs gene expression profile revealed the role of thrombin in the pathogenesis of atherosclerosis. | 1 |
| 37112918 | 2023 | Inflammatory Response and Activation of Coagulation after COVID-19 Infection. | 5 |
Citation
Dessen P
F2 (coagulation factor II, thrombin)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/40520/f2-(coagulation-factor-ii-thrombin)
