F2R (coagulation factor II thrombin receptor)

2003-06-01  

Identity

HGNC
F2R
LOCATION
5q13.3
LOCUSID
2149
ALIAS
CF2R,HTR,PAR-1,PAR1,TR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2149
MIM: 187930
HGNC: 3537
Ensembl: ENSG00000181104

Variants:

dbSNP: 2149
ClinVar: 2149
TCGA: ENSG00000181104
COSMIC: F2R

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181104ENST00000319211P25116
ENSG00000181104ENST00000319211A0A024RAP7
ENSG00000181104ENST00000505600G3XAL6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Complement and coagulation cascadesKEGGko04610
Regulation of actin cytoskeletonKEGGko04810
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Complement and coagulation cascadesKEGGhsa04610
Regulation of actin cytoskeletonKEGGhsa04810
Pathways in cancerKEGGhsa05200
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Platelet activationKEGGhsa04611
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Thrombin signalling through proteinase activated receptors (PARs)REACTOMER-HSA-456926
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Common Pathway of Fibrin Clot FormationREACTOMER-HSA-140875
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA157F2GenePathwayassociated20938371
PA174GNAQGenePathwayassociated20938371
PA176GNB3GenePathwayassociated20938371
PA28764GNA11GenePathwayassociated20938371
PA28765GNA12GenePathwayassociated20938371
PA28766GNA13GenePathwayassociated20938371
PA28768GNA15GenePathwayassociated20938371

References

Pubmed IDYearTitleCitations
381151792024KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.0
381745612024Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin.1
381151792024KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.0
381745612024Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin.1
361093382023Elevated serum PAR-1 levels as an emerging biomarker of inflammation to predict the dengue infection severity.1
374793832023Stage lighting on PAR-1: a step further in the understanding of acquired focal and segmental glomerulosclerosis.0
374865322023Protease-Activated Receptor 1 (PAR1) Expression Contributes to HPV-Associated Oropharyngeal Cancer Prognosis.0
376785502023Thrombin receptor PAR1 silencing in endothelial colony-forming cells modifies stemness and vasculogenic properties.1
377221382023Protease-Activated Receptor 1-Mediated Damage of Podocytes in Diabetic Nephropathy.4
378061062023PAR1 regulates sepsis-induced vascular endothelial barrier dysfunction by mediating ERM phosphorylation via the RhoA/ROCK signaling pathway.1
361093382023Elevated serum PAR-1 levels as an emerging biomarker of inflammation to predict the dengue infection severity.1
374793832023Stage lighting on PAR-1: a step further in the understanding of acquired focal and segmental glomerulosclerosis.0
374865322023Protease-Activated Receptor 1 (PAR1) Expression Contributes to HPV-Associated Oropharyngeal Cancer Prognosis.0
376785502023Thrombin receptor PAR1 silencing in endothelial colony-forming cells modifies stemness and vasculogenic properties.1
377221382023Protease-Activated Receptor 1-Mediated Damage of Podocytes in Diabetic Nephropathy.4

Citation

Dessen P

F2R (coagulation factor II thrombin receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40521/f2r-(coagulation-factor-ii-thrombin-receptor)