FAT4 (FAT atypical cadherin 4)

2003-10-01  

Identity

HGNC
FAT4
LOCATION
4q28.1
LOCUSID
79633
ALIAS
CDHF14,CDHR11,FAT-J,FATJ,HKLLS2,NBLA00548,VMLDS2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79633
MIM: 612411
HGNC: 23109
Ensembl: ENSG00000196159

Variants:

dbSNP: 79633
ClinVar: 79633
TCGA: ENSG00000196159
COSMIC: FAT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196159ENST00000335110Q6V0I7
ENSG00000196159ENST00000394329Q6V0I7

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
357708462023Increased expression of FAT4 suppress metastasis of lung adenocarcinoma through regulating MAPK pathway and associated with immune cells infiltration.1
367972292023Structure of the planar cell polarity cadherins Fat4 and Dachsous1.1
368118002023Identification of FAT4 as a positive prognostic biomarker in DLBCL by comprehensive genomic analysis.0
377512462023Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients of Colon Cancer: Clinicopathologic Study.0
380556462023FAT4 loss initiates hepatocarcinogenesis through the switching of canonical to noncanonical WNT signaling pathways.0
357708462023Increased expression of FAT4 suppress metastasis of lung adenocarcinoma through regulating MAPK pathway and associated with immune cells infiltration.1
367972292023Structure of the planar cell polarity cadherins Fat4 and Dachsous1.1
368118002023Identification of FAT4 as a positive prognostic biomarker in DLBCL by comprehensive genomic analysis.0
377512462023Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients of Colon Cancer: Clinicopathologic Study.0
380556462023FAT4 loss initiates hepatocarcinogenesis through the switching of canonical to noncanonical WNT signaling pathways.0
360519992022A pan-cancer analysis of FAT atypical cadherin 4 (FAT4) in human tumors.2
360519992022A pan-cancer analysis of FAT atypical cadherin 4 (FAT4) in human tumors.2
341303592021FAT4 identified as a potential modifier of orofacial cleft laterality.3
341303592021FAT4 identified as a potential modifier of orofacial cleft laterality.3
323662342020FAT4 silencing promotes epithelial-to-mesenchymal transition and invasion via regulation of YAP and β-catenin activity in ovarian cancer.9

Citation

Dessen P

FAT4 (FAT atypical cadherin 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/40537/fat4-(fat-atypical-cadherin-4)