Identity
HGNC
LOCATION
11q13.2
LOCUSID
ALIAS
CXXC8,FBL11,FBL7,FBXL11,JHDM1A,LILINA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 22992
MIM: 605657
HGNC: 13606
Ensembl: ENSG00000173120
Variants:
dbSNP: 22992
ClinVar: 22992
TCGA: ENSG00000173120
COSMIC: KDM2A
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| HDMs demethylate histones | REACTOME | R-HSA-3214842 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37845585 | 2024 | Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis. | 1 |
| 37845585 | 2024 | Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis. | 1 |
| 36723950 | 2023 | Stabilization of nuclear β-catenin by inhibiting KDM2A mediates cerebral ischemic tolerance. | 2 |
| 36991019 | 2023 | Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance. | 3 |
| 37311054 | 2023 | Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma. | 1 |
| 37751135 | 2023 | Biological Functions of the KDM2 Family of Histone Demethylases. | 1 |
| 36723950 | 2023 | Stabilization of nuclear β-catenin by inhibiting KDM2A mediates cerebral ischemic tolerance. | 2 |
| 36991019 | 2023 | Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance. | 3 |
| 37311054 | 2023 | Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma. | 1 |
| 37751135 | 2023 | Biological Functions of the KDM2 Family of Histone Demethylases. | 1 |
| 35537449 | 2022 | NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition. | 14 |
| 35697678 | 2022 | Histone H3K36me2 demethylase KDM2A promotes bladder cancer progression through epigenetically silencing RARRES3. | 6 |
| 35932580 | 2022 | KDM2A plays a dual role in regulating the expression of malignancy-related genes in esophageal squamous cell carcinoma. | 0 |
| 36084547 | 2022 | Histone demethylase KDM2A suppresses EGF-TSPAN8 pathway to inhibit breast cancer cell migration and invasion in vitro. | 1 |
| 35537449 | 2022 | NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition. | 14 |
Citation
Dessen P
KDM2A (lysine demethylase 2A)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/40540/kdm2a-(lysine-demethylase-2a)
