FBXW7 (F-box and WD repeat domain containing 7)

2003-02-01  

Identity

HGNC
FBXW7
LOCATION
4q31.3
LOCUSID
55294
ALIAS
AGO,CDC4,FBW6,FBW7,FBX30,FBXO30,FBXW6,SEL-10,SEL10,hAgo,hCdc4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55294
MIM: 606278
HGNC: 16712
Ensembl: ENSG00000109670

Variants:

dbSNP: 55294
ClinVar: 55294
TCGA: ENSG00000109670
COSMIC: FBXW7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109670ENST00000281708Q969H0
ENSG00000109670ENST00000296555Q969H0
ENSG00000109670ENST00000393956Q969H0
ENSG00000109670ENST00000603548Q969H0
ENSG00000109670ENST00000603841Q969H0
ENSG00000109670ENST00000604872S4R3U4
ENSG00000109670ENST00000605042S4R3N3
ENSG00000109670ENST00000642901G0Z2K0
ENSG00000109670ENST00000643834G0Z2K0
ENSG00000109670ENST00000647166G0Z2K0

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
SCF-FBW7 complexKEGGhsa_M00387
SCF-FBW7 complexKEGGM00387
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
FBXW7 Mutants and NOTCH1 in CancerREACTOMER-HSA-2644605
Loss of Function of FBXW7 in Cancer and NOTCH1 SignalingREACTOMER-HSA-2644607
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382449482024FBXW7 polymorphism asserts susceptibility to colorectal cancer.0
382680322024Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition.0
382795652024ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells.0
384839882024Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7.3
385083122024The SCF-FBW7β E3 ligase mediates ubiquitination and degradation of the serine/threonine protein kinase PINK1.0
388922102024Transcriptional Up-Regulation of FBXW7 by K(Ca)1.1 K(+) Channel Inhibition through the Nrf2 Signaling Pathway in Human Prostate Cancer LNCaP Cell Spheroid Model.0
382449482024FBXW7 polymorphism asserts susceptibility to colorectal cancer.0
382680322024Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition.0
382795652024ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells.0
384839882024Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7.3
385083122024The SCF-FBW7β E3 ligase mediates ubiquitination and degradation of the serine/threonine protein kinase PINK1.0
388922102024Transcriptional Up-Regulation of FBXW7 by K(Ca)1.1 K(+) Channel Inhibition through the Nrf2 Signaling Pathway in Human Prostate Cancer LNCaP Cell Spheroid Model.0
363228172023FBXW7β isoform drives transcriptional activation of the proinflammatory TNF cluster in human pro-B cells.2
364810942023FBXW7 Enhances Cisplatin-Induced Apoptosis in Oral Cancer Cell Lines.0
369341042023FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2.5

Citation

Dessen P

FBXW7 (F-box and WD repeat domain containing 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40542