Identity
HGNC
LOCATION
4q31.3
LOCUSID
ALIAS
AGO,CDC4,FBW6,FBW7,FBX30,FBXO30,FBXW6,SEL-10,SEL10,hAgo,hCdc4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55294
MIM: 606278
HGNC: 16712
Ensembl: ENSG00000109670
Variants:
dbSNP: 55294
ClinVar: 55294
TCGA: ENSG00000109670
COSMIC: FBXW7
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38244948 | 2024 | FBXW7 polymorphism asserts susceptibility to colorectal cancer. | 0 |
| 38268032 | 2024 | Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition. | 0 |
| 38279565 | 2024 | ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells. | 0 |
| 38483988 | 2024 | Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7. | 3 |
| 38508312 | 2024 | The SCF-FBW7β E3 ligase mediates ubiquitination and degradation of the serine/threonine protein kinase PINK1. | 0 |
| 38892210 | 2024 | Transcriptional Up-Regulation of FBXW7 by K(Ca)1.1 K(+) Channel Inhibition through the Nrf2 Signaling Pathway in Human Prostate Cancer LNCaP Cell Spheroid Model. | 0 |
| 38244948 | 2024 | FBXW7 polymorphism asserts susceptibility to colorectal cancer. | 0 |
| 38268032 | 2024 | Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition. | 0 |
| 38279565 | 2024 | ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells. | 0 |
| 38483988 | 2024 | Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7. | 3 |
| 38508312 | 2024 | The SCF-FBW7β E3 ligase mediates ubiquitination and degradation of the serine/threonine protein kinase PINK1. | 0 |
| 38892210 | 2024 | Transcriptional Up-Regulation of FBXW7 by K(Ca)1.1 K(+) Channel Inhibition through the Nrf2 Signaling Pathway in Human Prostate Cancer LNCaP Cell Spheroid Model. | 0 |
| 36322817 | 2023 | FBXW7β isoform drives transcriptional activation of the proinflammatory TNF cluster in human pro-B cells. | 2 |
| 36481094 | 2023 | FBXW7 Enhances Cisplatin-Induced Apoptosis in Oral Cancer Cell Lines. | 0 |
| 36934104 | 2023 | FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2. | 5 |
Citation
Dessen P
FBXW7 (F-box and WD repeat domain containing 7)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40542/fbxw7-(f-box-and-wd-repeat-domain-containing-7)
