FER (FER tyrosine kinase)

2003-02-01  

Identity

HGNC
FER
LOCATION
5q21.3
LOCUSID
2241
ALIAS
PPP1R74,TYK3,p94-Fer
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2241
MIM: 176942
HGNC: 3655
Ensembl: ENSG00000151422

Variants:

dbSNP: 2241
ClinVar: 2241
TCGA: ENSG00000151422
COSMIC: FER

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151422ENST00000281092P16591
ENSG00000151422ENST00000281092W0S0X4
ENSG00000151422ENST00000438717W0S4B9
ENSG00000151422ENST00000504143D6RAF9
ENSG00000151422ENST00000618353P16591
ENSG00000151422ENST00000628534A0A0D9SEV4

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Adherens junctionKEGGko04520
Adherens junctionKEGGhsa04520
Signal TransductionREACTOMER-HSA-162582
Signaling by SCF-KITREACTOMER-HSA-1433557

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
119947472002Closing in on the biological functions of Fps/Fes and Fer.72
255334912015Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study.48
197382022009The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration.44
198356032009Identification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cells.33
191475452009The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth.20
217008792011Novel locus FER is associated with serum HMW adiponectin levels.17
215188682011FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB.16
189857482008Expression of Fer testis (FerT) tyrosine kinase transcript variants and distribution sites of FerT during the development of the acrosome-acroplaxome-manchette complex in rat spermatids.14
167323232006Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells.13

Citation

Dessen P

FER (FER tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40544/fer-(fer-tyrosine-kinase)