Identity
HGNC
LOCATION
5q21.3
LOCUSID
ALIAS
PPP1R74,TYK3,p94-Fer
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2241
MIM: 176942
HGNC: 3655
Ensembl: ENSG00000151422
Variants:
dbSNP: 2241
ClinVar: 2241
TCGA: ENSG00000151422
COSMIC: FER
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Adherens junction | KEGG | ko04520 |
| Adherens junction | KEGG | hsa04520 |
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by SCF-KIT | REACTOME | R-HSA-1433557 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35550247 | 2022 | FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells. | 7 |
| 35550247 | 2022 | FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells. | 7 |
| 33411917 | 2021 | Phosphorylation of PKCδ by FER tips the balance from EGFR degradation to recycling. | 11 |
| 33430475 | 2021 | Fer and FerT Govern Mitochondrial Susceptibility to Metformin and Hypoxic Stress in Colon and Lung Carcinoma Cells. | 5 |
| 33806191 | 2021 | Loss of Fer Jeopardizes Metabolic Plasticity and Mitochondrial Homeostasis in Lung and Breast Carcinoma Cells. | 4 |
| 33411917 | 2021 | Phosphorylation of PKCδ by FER tips the balance from EGFR degradation to recycling. | 11 |
| 33430475 | 2021 | Fer and FerT Govern Mitochondrial Susceptibility to Metformin and Hypoxic Stress in Colon and Lung Carcinoma Cells. | 5 |
| 33806191 | 2021 | Loss of Fer Jeopardizes Metabolic Plasticity and Mitochondrial Homeostasis in Lung and Breast Carcinoma Cells. | 4 |
| 29099290 | 2020 | FER mediated HGF-independent regulation of HGFR/MET activates RAC1-PAK1 pathway to potentiate metastasis in ovarian cancer. | 7 |
| 31746983 | 2020 | FER and FES tyrosine kinase fusions in follicular T-cell lymphoma. | 8 |
| 29099290 | 2020 | FER mediated HGF-independent regulation of HGFR/MET activates RAC1-PAK1 pathway to potentiate metastasis in ovarian cancer. | 7 |
| 31746983 | 2020 | FER and FES tyrosine kinase fusions in follicular T-cell lymphoma. | 8 |
| 29208465 | 2018 | A curvature-dependent membrane binding by tyrosine kinase Fer involves an intrinsically disordered region. | 5 |
| 29540831 | 2018 | FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion. | 17 |
| 29907877 | 2018 | Electroporation-mediated delivery of FER gene enhances innate immune response and improves survival in a murine model of pneumonia. | 10 |
Citation
Dessen P
FER (FER tyrosine kinase)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40544/fer-(fer-tyrosine-kinase)
