FGF12 (fibroblast growth factor 12)

2003-02-01  

Identity

HGNC
LOCATION
3q28
LOCUSID
ALIAS
DEE47,EIEE47,FGF12B,FHF1
FUSION GENES

Other Information

Locus ID:

NCBI: 2257
MIM: 601513
HGNC: 3668
Ensembl: ENSG00000114279

Variants:

dbSNP: 2257
ClinVar: 2257
TCGA: ENSG00000114279
COSMIC: FGF12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114279ENST00000418610C9JIN3
ENSG00000114279ENST00000430714C9JEN8
ENSG00000114279ENST00000445105P61328
ENSG00000114279ENST00000448795C9JUK8
ENSG00000114279ENST00000450716P61328
ENSG00000114279ENST00000454309P61328

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Regulation of actin cytoskeletonKEGGko04810
MelanomaKEGGko05218
MAPK signaling pathwayKEGGhsa04010
Regulation of actin cytoskeletonKEGGhsa04810
Pathways in cancerKEGGhsa05200
MelanomaKEGGhsa05218
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 0 - rapid depolarisationREACTOMER-HSA-5576892
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

References

Pubmed IDYearTitleCitations
360295532022Modulating effects of FGF12 variants on Na(V)1.2 and Na(V)1.6 being associated with developmental and epileptic encephalopathy and Autism spectrum disorder: A case series.6
360295532022Modulating effects of FGF12 variants on Na(V)1.2 and Na(V)1.6 being associated with developmental and epileptic encephalopathy and Autism spectrum disorder: A case series.6
333499182021Genetic diagnosis of infantile-onset epilepsy in the clinic: Application of whole-exome sequencing following epilepsy gene panel testing.11
336293032021HMGN5 promotes invasion and migration of colorectal cancer through activating FGF/FGFR pathway.1
336391592021Ca(2+)-saturated calmodulin binds tightly to the N-terminal domain of A-type fibroblast growth factor homologous factors.5
339822892021Early onset epilepsy and sudden unexpected death in epilepsy with cardiac arrhythmia in mice carrying the early infantile epileptic encephalopathy 47 gain-of-function FHF1(FGF12) missense mutation.8
333499182021Genetic diagnosis of infantile-onset epilepsy in the clinic: Application of whole-exome sequencing following epilepsy gene panel testing.11
336293032021HMGN5 promotes invasion and migration of colorectal cancer through activating FGF/FGFR pathway.1
336391592021Ca(2+)-saturated calmodulin binds tightly to the N-terminal domain of A-type fibroblast growth factor homologous factors.5
339822892021Early onset epilepsy and sudden unexpected death in epilepsy with cardiac arrhythmia in mice carrying the early infantile epileptic encephalopathy 47 gain-of-function FHF1(FGF12) missense mutation.8
323578922020FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner.17
326452202020Defining the phenotype of FHF1 developmental and epileptic encephalopathy.6
329508102020A functional variant rs1464938 in the promoter of fibroblast growth factor 12 is associated with an increased risk of bladder transitional cell carcinoma.1
323578922020FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner.17
326452202020Defining the phenotype of FHF1 developmental and epileptic encephalopathy.6

Citation

Dessen P

FGF12 (fibroblast growth factor 12)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40552/fgf12-(fibroblast-growth-factor-12)