FGFR1OP2 (FGFR1 oncogene partner 2)

2003-12-01 Affiliation

Identity

HGNC

FGFR1OP2

LOCATION

12p11.23

LOCUSID

26127

ALIAS

HSPC123-like,WIT3.0

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 26127
MIM: 608858
HGNC: 23098
Ensembl: ENSG00000111790

Variants:

dbSNP: 26127
ClinVar: 26127
TCGA: ENSG00000111790
COSMIC: FGFR1OP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000111790	ENST00000229395	Q9NVK5
ENSG00000111790	ENST00000327214	Q9NVK5
ENSG00000111790	ENST00000544111	F5GX47
ENSG00000111790	ENST00000546072	Q9NVK5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by FGFR in disease	REACTOME	R-HSA-1226099
Signaling by FGFR1 in disease	REACTOME	R-HSA-5655302
FGFR1 mutant receptor activation	REACTOME	R-HSA-1839124
Signaling by cytosolic FGFR1 fusion mutants	REACTOME	R-HSA-1839117

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA164924492	brivanib	Chemical	Pathway	associated	20124951
PA26880	CRK	Gene	Pathway	associated	20124951
PA28115	FGF2	Gene	Pathway	associated	20124951
PA33304	PIK3C2A	Gene	Pathway	associated	20124951
PA33305	PIK3C2B	Gene	Pathway	associated	20124951

References

Pubmed ID	Year	Title	Citations
22880093	2012	Association between FGFR1OP2/wit3.0 polymorphisms and residual ridge resorption of mandible in Korean population.	5
22880093	2012	Association between FGFR1OP2/wit3.0 polymorphisms and residual ridge resorption of mandible in Korean population.	5
21283824	2011	A genetic association study of single nucleotide polymorphisms in FGFR1OP2/wit3.0 and long-term atrophy of edentulous mandible.	5
21283824	2011	A genetic association study of single nucleotide polymorphisms in FGFR1OP2/wit3.0 and long-term atrophy of edentulous mandible.	5
19959814	2010	Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure.	16
20734064	2010	A large-scale candidate gene association study of age at menarche and age at natural menopause.	57
19959814	2010	Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure.	16
20734064	2010	A large-scale candidate gene association study of age at menarche and age at natural menopause.	57
15034873	2004	Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome.	26
15034873	2004	Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome.	26

Citation

Dessen P

FGFR1OP2 (FGFR1 oncogene partner 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40569/fgfr1op2-(fgfr1-oncogene-partner-2)