FGR (FGR proto-oncogene, Src family tyrosine kinase)

2003-02-01  

Identity

HGNC
LOCATION
1p35.3
LOCUSID
ALIAS
SRC2,c-fgr,c-src2,p55-Fgr,p55c-fgr,p58-Fgr,p58c-fgr
FUSION GENES

Other Information

Locus ID:

NCBI: 2268
MIM: 164940
HGNC: 3697
Ensembl: ENSG00000000938

Variants:

dbSNP: 2268
ClinVar: 2268
TCGA: ENSG00000000938
COSMIC: FGR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000000938ENST00000374003P09769
ENSG00000000938ENST00000374004P09769
ENSG00000000938ENST00000374005P09769
ENSG00000000938ENST00000399173P09769
ENSG00000000938ENST00000457296Q5TGY6

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
FCGR activationREACTOMER-HSA-2029481
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet sensitization by LDLREACTOMER-HSA-432142
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
238964102013The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.30
213007582011Functional roles of Src and Fgr in ovarian carcinoma.23
178450552007Coactivator assembly at the promoter: efficient recruitment of SRC2 is coupled to cooperative DNA binding by the progesterone receptor.19
200561782010Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.5
297635502018Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo.5
259724882015Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation.4
273248242016A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma.3
303529502018The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation.3
119288062002Inhibition of receptor-dependent urokinase signaling by specific Ser to Glu substitutions.2
285851442017Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer.1

Citation

Dessen P

FGR (FGR proto-oncogene, Src family tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40572/fgr-(fgr-proto-oncogene-src-family-tyrosine-kinase)