FGR (FGR proto-oncogene, Src family tyrosine kinase)

2003-02-01  

Identity

HGNC
LOCATION
1p35.3
LOCUSID
ALIAS
SRC2,c-fgr,c-src2,p55-Fgr,p55c-fgr,p58-Fgr,p58c-fgr
FUSION GENES

Other Information

Locus ID:

NCBI: 2268
MIM: 164940
HGNC: 3697
Ensembl: ENSG00000000938

Variants:

dbSNP: 2268
ClinVar: 2268
TCGA: ENSG00000000938
COSMIC: FGR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000000938ENST00000374003P09769
ENSG00000000938ENST00000374004P09769
ENSG00000000938ENST00000374005P09769
ENSG00000000938ENST00000399173P09769
ENSG00000000938ENST00000457296Q5TGY6

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
FCGR activationREACTOMER-HSA-2029481
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet sensitization by LDLREACTOMER-HSA-432142
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371162922023Variants in PSMB9 and FGR differentially affect Parkinson's disease risk in GBA and LRRK2 mutation carriers.0
371162922023Variants in PSMB9 and FGR differentially affect Parkinson's disease risk in GBA and LRRK2 mutation carriers.0
349024302022A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr.6
349024302022A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr.6
317904992019Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance.18
317904992019Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance.18
297635502018Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo.26
303529502018The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation.18
297635502018Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo.26
303529502018The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation.18
285851442017Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer.4
285851442017Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer.4
273248242016A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma.5
273248242016A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma.5
259724882015Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation.14

Citation

Dessen P

FGR (FGR proto-oncogene, Src family tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40572/fgr-(fgr-proto-oncogene-src-family-tyrosine-kinase)