FOLH1 (folate hydrolase 1)

2003-02-01  

Identity

HGNC
LOCATION
11p11.12
LOCUSID
ALIAS
FGCP,FOLH,GCP2,GCPII,NAALAD1,NAALAdase,PSM,PSMA,mGCP

Other Information

Locus ID:

NCBI: 2346
MIM: 600934
HGNC: 3788
Ensembl: ENSG00000086205

Variants:

dbSNP: 2346
ClinVar: 2346
TCGA: ENSG00000086205
COSMIC: FOLH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000086205ENST00000256999Q04609
ENSG00000086205ENST00000340334Q04609
ENSG00000086205ENST00000356696Q04609
ENSG00000086205ENST00000525826E9PMK6
ENSG00000086205ENST00000529117E9PKM3
ENSG00000086205ENST00000529648E9PLV0
ENSG00000086205ENST00000533034Q04609
ENSG00000086205ENST00000533510E9PI29

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Alanine, aspartate and glutamate metabolismKEGGko00250
Alanine, aspartate and glutamate metabolismKEGGhsa00250
Metabolic pathwaysKEGGhsa01100
Vitamin digestion and absorptionKEGGko04977
Vitamin digestion and absorptionKEGGhsa04977
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPD22838948
PA450379mercaptopurineChemicalClinicalAnnotationassociatedPD22838948
PA450428methotrexateChemicalClinicalAnnotationassociatedPD22838948

References

Pubmed IDYearTitleCitations
190609112009Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.392
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
216063472011Noninvasive measurement of androgen receptor signaling with a positron-emitting radiopharmaceutical that targets prostate-specific membrane antigen.76
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
158379262005Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase.57
197161602009Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers.54
145280232003A novel cytoplasmic tail MXXXL motif mediates the internalization of prostate-specific membrane antigen.52
158405612005Is prostate-specific membrane antigen a multifunctional protein?50
298077812018Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication.43
193437342009Expression of the gastrin-releasing peptide receptor, the prostate stem cell antigen and the prostate-specific membrane antigen in lymph node and bone metastases of prostate cancer.38

Citation

Dessen P

FOLH1 (folate hydrolase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40619/folh1-(folate-hydrolase-1)