Identity
HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
FBP,FOLR,FRalpha,NCFTD
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2348
MIM: 136430
HGNC: 3791
Ensembl: ENSG00000110195
Variants:
dbSNP: 2348
ClinVar: 2348
TCGA: ENSG00000110195
COSMIC: FOLR1
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA450428 | methotrexate | Chemical | Pathway | associated | 21317831 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36396012 | 2023 | Elevated expression of receptors for EGF, PDGF, transferrin and folate within murine and human lupus nephritis kidneys. | 2 |
| 36402875 | 2023 | Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes. | 15 |
| 37506533 | 2023 | Folate receptor alpha is widely expressed and a potential therapeutic target in uterine and ovarian carcinosarcoma. | 2 |
| 37883728 | 2023 | Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele. | 0 |
| 38057830 | 2023 | Cancer-associated fibroblasts induce sorafenib resistance of hepatocellular carcinoma cells through CXCL12/FOLR1. | 2 |
| 36396012 | 2023 | Elevated expression of receptors for EGF, PDGF, transferrin and folate within murine and human lupus nephritis kidneys. | 2 |
| 36402875 | 2023 | Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes. | 15 |
| 37506533 | 2023 | Folate receptor alpha is widely expressed and a potential therapeutic target in uterine and ovarian carcinosarcoma. | 2 |
| 37883728 | 2023 | Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele. | 0 |
| 38057830 | 2023 | Cancer-associated fibroblasts induce sorafenib resistance of hepatocellular carcinoma cells through CXCL12/FOLR1. | 2 |
| 35094917 | 2022 | Emerging roles for folate receptor FOLR1 in signaling and cancer. | 26 |
| 35545363 | 2022 | Association of periconceptional folate supplements and FOLR1 and FOLR2 gene polymorphisms with risk of congenital heart disease in offspring: A hospital-based case-control study. | 0 |
| 36245230 | 2022 | High expression of folate receptor alpha is associated with poor prognosis in patients with cervical cancer. | 2 |
| 36426547 | 2022 | High Expression of Folate Receptor Alpha (FOLR1) is Associated With Aggressive Tumor Behavior, Poor Response to Chemoradiotherapy, and Worse Survival in Rectal Cancer. | 4 |
| 35094917 | 2022 | Emerging roles for folate receptor FOLR1 in signaling and cancer. | 26 |
Citation
Dessen P
FOLR1 (folate receptor alpha)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40620/folr1-(folate-receptor-alpha)
