Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2355
MIM: 601575
HGNC: 3798
Ensembl: ENSG00000075426
Variants:
dbSNP: 2355
ClinVar: 2355
TCGA: ENSG00000075426
COSMIC: FOSL2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000075426 | ENST00000264716 | P15408 |
| ENSG00000075426 | ENST00000379619 | P15408 |
| ENSG00000075426 | ENST00000436647 | C9JCN8 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Osteoclast differentiation | KEGG | ko04380 |
| Osteoclast differentiation | KEGG | hsa04380 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA283 | MAPK8 | Gene | Pathway | associated | 23922006 | ||
| PA30621 | MAPK14 | Gene | Pathway | associated | 23922006 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38104183 | 2024 | Role of Fra-2 in cancer. | 2 |
| 38104183 | 2024 | Role of Fra-2 in cancer. | 2 |
| 36920708 | 2023 | Circ_0005615 Regulates the Progression of Colorectal Cancer Through the miR-873-5p/FOSL2 Signaling Pathway. | 5 |
| 37173651 | 2023 | Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factors. | 0 |
| 37370246 | 2023 | LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis. | 5 |
| 37380804 | 2023 | Chromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28. | 3 |
| 36920708 | 2023 | Circ_0005615 Regulates the Progression of Colorectal Cancer Through the miR-873-5p/FOSL2 Signaling Pathway. | 5 |
| 37173651 | 2023 | Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factors. | 0 |
| 37370246 | 2023 | LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis. | 5 |
| 37380804 | 2023 | Chromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28. | 3 |
| 34499807 | 2022 | Nucleolar localization of c-Jun. | 2 |
| 34693476 | 2022 | Fra-2 overexpression upregulates pro-metastatic cell-adhesion molecules, promotes pulmonary metastasis, and reduces survival in a spontaneous xenograft model of human breast cancer. | 3 |
| 34773569 | 2022 | Inhibition of FOSL2 aggravates the apoptosis of ovarian cancer cells by promoting the formation of inflammasomes. | 6 |
| 35034245 | 2022 | Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression. | 5 |
| 35511484 | 2022 | A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation. | 9 |
Citation
Dessen P
FOSL2 (FOS like 2, AP-1 transcription factor subunit)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40623/fosl2-(fos-like-2-ap-1-transcription-factor-subunit)
