Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9513
MIM: 605339
HGNC: 4024
Ensembl: ENSG00000129245
Variants:
dbSNP: 9513
ClinVar: 9513
TCGA: ENSG00000129245
COSMIC: FXR2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000129245 | ENST00000250113 | P51116 |
| ENSG00000129245 | ENST00000571597 | I3L1Z2 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| RNA transport | KEGG | ko03013 |
| RNA transport | KEGG | hsa03013 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447197 | Attention Deficit Disorder with Hyperactivity | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 29382897 | |
| PA450464 | methylphenidate | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 29382897 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38587486 | 2024 | LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation. | 2 |
| 38587486 | 2024 | LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation. | 2 |
| 32706158 | 2020 | Spatial control of nucleoporin condensation by fragile X-related proteins. | 13 |
| 32878499 | 2020 | Fragile X-related protein family: a double-edged sword in neurodevelopmental disorders and cancer. | 22 |
| 32706158 | 2020 | Spatial control of nucleoporin condensation by fragile X-related proteins. | 13 |
| 32878499 | 2020 | Fragile X-related protein family: a double-edged sword in neurodevelopmental disorders and cancer. | 22 |
| 28767039 | 2017 | FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion. | 18 |
| 28767039 | 2017 | FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion. | 18 |
| 26612855 | 2015 | Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes. | 29 |
| 26612855 | 2015 | Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes. | 29 |
| 20442204 | 2010 | Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P. | 43 |
| 21072162 | 2010 | Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2. | 37 |
| 20442204 | 2010 | Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P. | 43 |
| 21072162 | 2010 | Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2. | 37 |
| 19487368 | 2009 | Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs. | 67 |
Citation
Dessen P
FXR2 (FMR1 autosomal homolog 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/40651/fxr2-(fmr1-autosomal-homolog-2)
