GAS2 (growth arrest specific 2)

2003-02-01  

Identity

HGNC
GAS2
LOCATION
11p14.3
LOCUSID
2620
ALIAS
GAS-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2620
MIM: 602835
HGNC: 4167
Ensembl: ENSG00000148935

Variants:

dbSNP: 2620
ClinVar: 2620
TCGA: ENSG00000148935
COSMIC: GAS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148935ENST00000278187O43903
ENSG00000148935ENST00000454584O43903
ENSG00000148935ENST00000524701O43903
ENSG00000148935ENST00000528582E9PQ74
ENSG00000148935ENST00000532398E9PRR5
ENSG00000148935ENST00000533363E9PQ37
ENSG00000148935ENST00000534801E9PM28
ENSG00000148935ENST00000630668O43903

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Caspase-mediated cleavage of cytoskeletal proteinsREACTOMER-HSA-264870

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
360540802022Growth arrest-specific protein 2 (GAS2) interacts with CXCR4 to promote T-cell leukemogenesis partially via c-MYC.0
360540802022Growth arrest-specific protein 2 (GAS2) interacts with CXCR4 to promote T-cell leukemogenesis partially via c-MYC.0
331033012021Growth arrest-specific 2 protein family: Structure and function.15
339642052021Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.13
331033012021Growth arrest-specific 2 protein family: Structure and function.15
339642052021Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.13
325728852020UCHL1 enhances the malignant development of glioma via targeting GAS2.3
325728852020UCHL1 enhances the malignant development of glioma via targeting GAS2.3
315280962019Growth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis.11
315280962019Growth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis.11
270859732016Upregulation of the growth arrest-specific-2 in recurrent colorectal cancers, and its susceptibility to chemotherapy in a model cell system.11
270859732016Upregulation of the growth arrest-specific-2 in recurrent colorectal cancers, and its susceptibility to chemotherapy in a model cell system.11
259259442015Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis.19
263583202015GAS2-Calpain2 axis contributes to the growth of leukemic cells.5
259259442015Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis.19

Citation

Dessen P

GAS2 (growth arrest specific 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40685/gas2-(growth-arrest-specific-2)