GAS8 (growth arrest specific 8)

2003-06-01   Dessen P  

Identity

HGNC
GAS8
LOCATION
16q24.3
LOCUSID
2622
ALIAS
CILD33,DRC4,GAS11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2622
MIM: 605178
HGNC: 4166
Ensembl: ENSG00000141013

Variants:

dbSNP: 2622
ClinVar: 2622
TCGA: ENSG00000141013
COSMIC: GAS8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141013ENST00000268699O95995
ENSG00000141013ENST00000268699A0A384MR00
ENSG00000141013ENST00000536122O95995
ENSG00000141013ENST00000561675H3BUA7
ENSG00000141013ENST00000564392H3BP65
ENSG00000141013ENST00000565062H3BQT7
ENSG00000141013ENST00000566266H3BME0
ENSG00000141013ENST00000620723A0A087WZT7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'on' stateREACTOMER-HSA-5632684
Activation of SMOREACTOMER-HSA-5635838

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
339425562021LncRNA GAS8-AS1 downregulates lncRNA NEAT1 to inhibit glioblastoma cell proliferation.6
339425562021LncRNA GAS8-AS1 downregulates lncRNA NEAT1 to inhibit glioblastoma cell proliferation.6
321650892020Expression analysis of growth arrest specific 8 and its anti-sense in breast cancer tissues.1
321650892020Expression analysis of growth arrest specific 8 and its anti-sense in breast cancer tissues.1
310038312019GAS8 and its naturally occurring antisense RNA as biomarkers in multiple sclerosis.5
310038312019GAS8 and its naturally occurring antisense RNA as biomarkers in multiple sclerosis.5
293273012018LncRNA GAS8-AS1 inhibits cell proliferation through ATG5-mediated autophagy in papillary thyroid cancer.29
302281802018The long noncoding RNA GAS8-AS1 suppresses hepatocarcinogenesis by epigenetically activating the tumor suppressor GAS8.27
293273012018LncRNA GAS8-AS1 inhibits cell proliferation through ATG5-mediated autophagy in papillary thyroid cancer.29
302281802018The long noncoding RNA GAS8-AS1 suppresses hepatocarcinogenesis by epigenetically activating the tumor suppressor GAS8.27
271201272016Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal Disorganization.21
274720562016Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease.20
271201272016Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal Disorganization.21
274720562016Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease.20
263875942015Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex.59

Citation

Dessen P

GAS8 (growth arrest specific 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40688/gas8-(growth-arrest-specific-8)