RNASEL (ribonuclease L)

2003-02-01  

Identity

HGNC
LOCATION
1q25.3
LOCUSID
ALIAS
PRCA1,RNS4

Other Information

Locus ID:

NCBI: 6041
MIM: 180435
HGNC: 10050
Ensembl: ENSG00000135828

Variants:

dbSNP: 6041
ClinVar: 6041
TCGA: ENSG00000135828
COSMIC: RNASEL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135828ENST00000367559Q05823
ENSG00000135828ENST00000539397Q05823

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Transmembrane transport of small moleculesREACTOMER-HSA-382551
ABC-family proteins mediated transportREACTOMER-HSA-382556

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
356552652022Carriage of mutations R462Q (rs 486907) and D541E (rs 627928) of the RNASEL gene and risk factors in patients with prostate cancer in Burkina Faso.2
356552652022Carriage of mutations R462Q (rs 486907) and D541E (rs 627928) of the RNASEL gene and risk factors in patients with prostate cancer in Burkina Faso.2
336706462021ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections.2
340312502021Zika virus employs the host antiviral RNase L protein to support replication factory assembly.8
342722272021OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis.15
336706462021ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections.2
340312502021Zika virus employs the host antiviral RNase L protein to support replication factory assembly.8
342722272021OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis.15
318965772020RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules.37
328308492020Sunitinib inhibits RNase L by destabilizing its active dimer conformation.6
318965772020RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules.37
328308492020Sunitinib inhibits RNase L by destabilizing its active dimer conformation.6
312765922019The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides.48
316866702019Evidence from 40 Studies that 2 Common Single-Nucleotide Polymorphisms (SNPs) of RNASEL Gene Affect Prostate Cancer Susceptibility: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-Compliant Meta-Analysis.1
312765922019The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides.48

Citation

Dessen P

RNASEL (ribonuclease L)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/407/cdc7-(cell-division-cycle-7)