GRIP1 (glutamate receptor interacting protein 1)

2003-02-01 Affiliation

Identity

HGNC

GRIP1

LOCATION

12q14.3

LOCUSID

23426

ALIAS

FRASRS3,GRIP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23426
MIM: 604597
HGNC: 18708
Ensembl: ENSG00000155974

Variants:

dbSNP: 23426
ClinVar: 23426
TCGA: ENSG00000155974
COSMIC: GRIP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000155974	ENST00000359742	Q9Y3R0
ENSG00000155974	ENST00000398016	Q9Y3R0
ENSG00000155974	ENST00000535002	H0YFY3
ENSG00000155974	ENST00000536215	F5H4Q7
ENSG00000155974	ENST00000538164	H0YFK8
ENSG00000155974	ENST00000538211	F5H4N6
ENSG00000155974	ENST00000538373	F5H4M4
ENSG00000155974	ENST00000539540	F5H5I0
ENSG00000155974	ENST00000540433	F5H4P8
ENSG00000155974	ENST00000540854	H0YGF1
ENSG00000155974	ENST00000541947	F5H3G9
ENSG00000155974	ENST00000542309	F5H424
ENSG00000155974	ENST00000543172	H0YGM4
ENSG00000155974	ENST00000545666	F5H3F9
ENSG00000155974	ENST00000643019	A0A2R8Y6S7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	REACTOME	R-HSA-399721
Trafficking of AMPA receptors	REACTOME	R-HSA-399719
Trafficking of GluR2-containing AMPA receptors	REACTOME	R-HSA-416993

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
31757889	2019	The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C.	27
31757889	2019	The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C.	27
27425598	2017	Structural insight into GRIP1-PDZ6 in Alzheimer's disease: study from protein expression data to molecular dynamics simulations.	2
29170386	2017	Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages.	20
27425598	2017	Structural insight into GRIP1-PDZ6 in Alzheimer's disease: study from protein expression data to molecular dynamics simulations.	2
29170386	2017	Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages.	20
27941904	2016	The role of GRIP1 and ephrin B3 in blood pressure control and vascular smooth muscle cell contractility.	10
27941904	2016	The role of GRIP1 and ephrin B3 in blood pressure control and vascular smooth muscle cell contractility.	10
25673849	2015	Trip6 promotes dendritic morphogenesis through dephosphorylated GRIP1-dependent myosin VI and F-actin organization.	7
25673849	2015	Trip6 promotes dendritic morphogenesis through dephosphorylated GRIP1-dependent myosin VI and F-actin organization.	7
24700879	2014	Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.	47
24700879	2014	Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.	47
20877300	2012	Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.	42
22510445	2012	Mutations in GRIP1 cause Fraser syndrome.	26
20877300	2012	Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.	42

Citation

Dessen P

GRIP1 (glutamate receptor interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40754/grip1-(glutamate-receptor-interacting-protein-1)