GRIP1 (glutamate receptor interacting protein 1)

2003-02-01  

Identity

HGNC
LOCATION
12q14.3
LOCUSID
ALIAS
FRASRS3,GRIP
FUSION GENES

Other Information

Locus ID:

NCBI: 23426
MIM: 604597
HGNC: 18708
Ensembl: ENSG00000155974

Variants:

dbSNP: 23426
ClinVar: 23426
TCGA: ENSG00000155974
COSMIC: GRIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155974ENST00000359742Q9Y3R0
ENSG00000155974ENST00000398016Q9Y3R0
ENSG00000155974ENST00000535002H0YFY3
ENSG00000155974ENST00000536215F5H4Q7
ENSG00000155974ENST00000538164H0YFK8
ENSG00000155974ENST00000538211F5H4N6
ENSG00000155974ENST00000538373F5H4M4
ENSG00000155974ENST00000539540F5H5I0
ENSG00000155974ENST00000540433F5H4P8
ENSG00000155974ENST00000540854H0YGF1
ENSG00000155974ENST00000541947F5H3G9
ENSG00000155974ENST00000542309F5H424
ENSG00000155974ENST00000543172H0YGM4
ENSG00000155974ENST00000545666F5H3F9
ENSG00000155974ENST00000643019A0A2R8Y6S7

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOMER-HSA-399721
Trafficking of AMPA receptorsREACTOMER-HSA-399719
Trafficking of GluR2-containing AMPA receptorsREACTOMER-HSA-416993

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197363512009Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.151
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
120114652002Differential roles for NSF and GRIP/ABP in AMPA receptor cycling.49
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
213831722011Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism.32
247008792014Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.32
152263182004A four PDZ domain-containing splice variant form of GRIP1 is localized in GABAergic and glutamatergic synapses in the brain.27
208773002012Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.26
225104452012Mutations in GRIP1 cause Fraser syndrome.23
181550422008Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1.13

Citation

Dessen P

GRIP1 (glutamate receptor interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40754/grip1-(glutamate-receptor-interacting-protein-1)