GRK1 (G protein-coupled receptor kinase 1)

2003-11-01 Affiliation

Identity

HGNC

GRK1

LOCATION

13q34

LOCUSID

6011

ALIAS

GPRK1,RHOK,RK

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6011
MIM: 180381
HGNC: 10013
Ensembl: ENSG00000185974

Variants:

dbSNP: 6011
ClinVar: 6011
TCGA: ENSG00000185974
COSMIC: GRK1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000185974	ENST00000335678	Q15835

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Phototransduction	KEGG	ko04744
Phototransduction	KEGG	hsa04744
Signal Transduction	REACTOME	R-HSA-162582
Visual phototransduction	REACTOME	R-HSA-2187338
The phototransduction cascade	REACTOME	R-HSA-2514856
Inactivation, recovery and regulation of the phototransduction cascade	REACTOME	R-HSA-2514859

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
33252155	2021	New variants and in silico analyses in GRK1 associated Oguchi disease.	4
34528284	2021	Non-genetic and genetic rewiring underlie adaptation to hypomorphic alleles of an essential gene.	3
34830487	2021	Disulfide Dimerization of Neuronal Calcium Sensor-1: Implications for Zinc and Redox Signaling.	6
33252155	2021	New variants and in silico analyses in GRK1 associated Oguchi disease.	4
34528284	2021	Non-genetic and genetic rewiring underlie adaptation to hypomorphic alleles of an essential gene.	3
34830487	2021	Disulfide Dimerization of Neuronal Calcium Sensor-1: Implications for Zinc and Redox Signaling.	6
32146548	2020	Wide-field true-colour imaging and clinical characterization of a novel GRK1 mutation in Oguchi disease.	5
32146548	2020	Wide-field true-colour imaging and clinical characterization of a novel GRK1 mutation in Oguchi disease.	5
28511019	2018	A novel GRK1 mutation in an Italian patient with Oguchi disease.	3
28511019	2018	A novel GRK1 mutation in an Italian patient with Oguchi disease.	3
26350504	2016	AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling.	7
27511724	2016	A novel missense mutation of the GRK1 gene in Oguchi disease.	6
26350504	2016	AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling.	7
27511724	2016	A novel missense mutation of the GRK1 gene in Oguchi disease.	6
25979333	2015	Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions.	23

Citation

Dessen P

GRK1 (G protein-coupled receptor kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40755/grk1-(g-protein-coupled-receptor-kinase-1)