GRP (gastrin releasing peptide)

2004-04-01  

Identity

HGNC
GRP
LOCATION
18q21.32
LOCUSID
2922
ALIAS
BN,GRP-10,preproGRP,proGRP

Other Information

Locus ID:

NCBI: 2922
MIM: 137260
HGNC: 4605
Ensembl: ENSG00000134443

Variants:

dbSNP: 2922
ClinVar: 2922
TCGA: ENSG00000134443
COSMIC: GRP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134443ENST00000256857P07492
ENSG00000134443ENST00000420468P07492
ENSG00000134443ENST00000420468A0A140VJM7
ENSG00000134443ENST00000456142H0Y5C5
ENSG00000134443ENST00000529320P07492
ENSG00000134443ENST00000530323H0YCH3

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
374097712024GRP/GRPR enhances alcohol-associated liver injury through the IRF1-mediated Caspase-1 inflammasome and NOX2-dependent ROS pathway.2
374097712024GRP/GRPR enhances alcohol-associated liver injury through the IRF1-mediated Caspase-1 inflammasome and NOX2-dependent ROS pathway.2
370888732023Evaluating the diagnostic and prognostic value of serum TuM2-PK, NSE, and ProGRP in small cell lung cancer.5
370888732023Evaluating the diagnostic and prognostic value of serum TuM2-PK, NSE, and ProGRP in small cell lung cancer.5
338606502021Circulating pro-gastrin releasing peptide (ProGRP) in patients with medullary thyroid carcinoma.6
338606502021Circulating pro-gastrin releasing peptide (ProGRP) in patients with medullary thyroid carcinoma.6
314121422020Expression and clinical value of gastrin-releasing peptide precursor in nephropathy and chronic kidney disease.3
318774162020The oncogenic and druggable hPG80 (Progastrin) is overexpressed in multiple cancers and detected in the blood of patients.8
318877952020Increased Progastrin-Releasing Peptide Expression is Associated with Progression in Gastric Cancer Patients.3
320452912020ProGRP AS A NOVEL BIOMARKER FOR THE DIFFERENTIAL DIAGNOSIS OF MEDULLARY THYROID CARCINOMA IN PATIENTS WITH THYROID NODULES.3
325527542020Gastrin-releasing peptide induces fibrotic response in MRC5s and proliferation in A549s.4
327911342020Serum ProGRP as a novel biomarker of bone metastasis in prostate cancer.3
314121422020Expression and clinical value of gastrin-releasing peptide precursor in nephropathy and chronic kidney disease.3
318774162020The oncogenic and druggable hPG80 (Progastrin) is overexpressed in multiple cancers and detected in the blood of patients.8
318877952020Increased Progastrin-Releasing Peptide Expression is Associated with Progression in Gastric Cancer Patients.3

Citation

Dessen P

GRP (gastrin releasing peptide)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/40758/cancer-prone-explorer/css/lib/hgnc