GSTA4 (glutathione S-transferase alpha 4)

2003-06-01  

Identity

HGNC
LOCATION
6p12.2
LOCUSID
ALIAS
GSTA4-4,GTA4
FUSION GENES

Other Information

Locus ID:

NCBI: 2941
MIM: 605450
HGNC: 4629
Ensembl: ENSG00000170899

Variants:

dbSNP: 2941
ClinVar: 2941
TCGA: ENSG00000170899
COSMIC: GSTA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170899ENST00000370959O15217
ENSG00000170899ENST00000370959A0A024RD58
ENSG00000170899ENST00000370960O15217
ENSG00000170899ENST00000370963O15217
ENSG00000170899ENST00000370963A0A024RD58
ENSG00000170899ENST00000457564Q5JW88

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
270653232016Glutathione S-transferase alpha 4 induction by activator protein 1 in colorectal cancer.17
270653232016Glutathione S-transferase alpha 4 induction by activator protein 1 in colorectal cancer.17
244035082014Collateral sensitivity to cisplatin in KB-8-5-11 drug-resistant cancer cells.6
244035082014Collateral sensitivity to cisplatin in KB-8-5-11 drug-resistant cancer cells.6
236501892013Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis.9
236501892013Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis.9
220380482012Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection.17
233300922012Expression of genes of glutathione transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in tumor cells during the formation of drug resistance to cisplatin.13
220380482012Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection.17
233300922012Expression of genes of glutathione transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in tumor cells during the formation of drug resistance to cisplatin.13
217512612011The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas.3
217512612011The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas.3
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.30
200853332010Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal.14
200977302010Antioxidant genes, diabetes and dietary antioxidants in association with risk of pancreatic cancer.18

Citation

Dessen P

GSTA4 (glutathione S-transferase alpha 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40767/gsta4-(glutathione-s-transferase-alpha-4)