GSTM2 (glutathione S-transferase mu 2)

2003-06-01  

Identity

HGNC
GSTM2
LOCATION
1p13.3
LOCUSID
2946
ALIAS
GST4,GSTM,GSTM2-2,GTHMUS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2946
MIM: 138380
HGNC: 4634
Ensembl: ENSG00000213366

Variants:

dbSNP: 2946
ClinVar: 2946
TCGA: ENSG00000213366
COSMIC: GSTM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213366ENST00000241337P28161
ENSG00000213366ENST00000241337A0A384P5E9
ENSG00000213366ENST00000369827E9PHN7
ENSG00000213366ENST00000369829E9PHN6
ENSG00000213366ENST00000369831F6XZQ7
ENSG00000213366ENST00000414179E9PGV1
ENSG00000213366ENST00000442650P28161
ENSG00000213366ENST00000460717P28161
ENSG00000213366ENST00000467579E9PLF1

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
360386612022GSTM2 is a key molecular determinant of resistance to SG-ARIs.1
360386612022GSTM2 is a key molecular determinant of resistance to SG-ARIs.1
335555462021Cellular Trafficking of Glutathione Transferase M2-2 Between U373MG and SHSY-S7 Cells is Mediated by Exosomes.7
335555462021Cellular Trafficking of Glutathione Transferase M2-2 Between U373MG and SHSY-S7 Cells is Mediated by Exosomes.7
325745612020Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage.67
325745612020Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage.67
275665762016Integrated analysis of genome-wide DNA methylation and gene expression profiles identifies potential novel biomarkers of rectal cancer.13
275665762016Integrated analysis of genome-wide DNA methylation and gene expression profiles identifies potential novel biomarkers of rectal cancer.13
243996502014Quantitative assessment of the effect of glutathione S-transferase genes GSTM1 and GSTT1 on hepatocellular carcinoma risk.11
248525192014Genetic susceptibility, residential radon, and lung cancer in a radon prone area.23
243996502014Quantitative assessment of the effect of glutathione S-transferase genes GSTM1 and GSTT1 on hepatocellular carcinoma risk.11
248525192014Genetic susceptibility, residential radon, and lung cancer in a radon prone area.23
236754692013The redox state of cytochrome c modulates resistance to methotrexate in human MCF7 breast cancer cells.5
240481942013Functional compensation of glutathione S-transferase M1 (GSTM1) null by another GST superfamily member, GSTM2.36
236754692013The redox state of cytochrome c modulates resistance to methotrexate in human MCF7 breast cancer cells.5

Citation

Dessen P

GSTM2 (glutathione S-transferase mu 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40769/gstm2-(glutathione-s-transferase-mu-2)