GSTM3 (glutathione S-transferase mu 3)

2003-06-01 Affiliation

Identity

HGNC

GSTM3

LOCATION

1p13.3

LOCUSID

2947

ALIAS

GST5,GSTB,GSTM3-3,GTM3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2947
MIM: 138390
HGNC: 4635
Ensembl: ENSG00000134202

Variants:

dbSNP: 2947
ClinVar: 2947
TCGA: ENSG00000134202
COSMIC: GSTM3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000134202	ENST00000256594	P21266
ENSG00000134202	ENST00000256594	Q6FGJ9
ENSG00000134202	ENST00000361066	P21266
ENSG00000134202	ENST00000361066	Q6FGJ9
ENSG00000134202	ENST00000540225	A0A0A0MTN3

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glutathione metabolism	KEGG	ko00480
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Glutathione metabolism	KEGG	hsa00480
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glutathione conjugation	REACTOME	R-HSA-156590
Platinum drug resistance	KEGG	ko01524
Platinum drug resistance	KEGG	hsa01524
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA443340	Anemia	Disease	VariantAnnotation	associated	PK	PD	19786980
PA443937	Drug Toxicity	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	19786980, 22188361
PA445204	Ovarian Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	19786980, 22188361
PA445301	Peripheral Nervous System Diseases	Disease	VariantAnnotation	associated	PK	PD	19786980
PA445846	Thrombocytopenia	Disease	VariantAnnotation	associated	PK	PD	19786980
PA449014	cisplatin	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	19786980, 22188361
PA449165	cyclophosphamide	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	19786980, 22188361
PA450688	olanzapine	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK		23559402

References

Pubmed ID	Year	Title	Citations
38228715	2024	GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.	0
38228715	2024	GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.	0
33121982	2021	Whole-proteome analysis of mesonephric-derived cancers describes new potential biomarkers.	6
33482859	2021	Low GSTM3 expression is associated with poor disease-free survival in resected esophageal squamous cell carcinoma.	2
34209254	2021	Glutathione S-Transferase M3 Is Associated with Glycolysis in Intrinsic Temozolomide-Resistant Glioblastoma Multiforme Cells.	11
33121982	2021	Whole-proteome analysis of mesonephric-derived cancers describes new potential biomarkers.	6
33482859	2021	Low GSTM3 expression is associated with poor disease-free survival in resected esophageal squamous cell carcinoma.	2
34209254	2021	Glutathione S-Transferase M3 Is Associated with Glycolysis in Intrinsic Temozolomide-Resistant Glioblastoma Multiforme Cells.	11
32645615	2020	GSTM3 variant is a novel genetic modifier in Brugada syndrome, a disease with risk of sudden cardiac death.	10
32645615	2020	GSTM3 variant is a novel genetic modifier in Brugada syndrome, a disease with risk of sudden cardiac death.	10
31172354	2019	LncRNA GAS5 regulates the proliferation, migration, invasion and apoptosis of brain glioma cells through targeting GSTM3 expression. The effect of LncRNA GAS5 on glioma cells.	31
31172354	2019	LncRNA GAS5 regulates the proliferation, migration, invasion and apoptosis of brain glioma cells through targeting GSTM3 expression. The effect of LncRNA GAS5 on glioma cells.	31
29569387	2018	A novel functional polymorphism of GSTM3 reduces clear cell renal cell carcinoma risk through enhancing its expression by interfering miR-556 binding.	5
30054830	2018	Oestrogen receptor-regulated glutathione S-transferase mu 3 expression attenuates hydrogen peroxide-induced cytotoxicity, which confers tamoxifen resistance on breast cancer cells.	9
29569387	2018	A novel functional polymorphism of GSTM3 reduces clear cell renal cell carcinoma risk through enhancing its expression by interfering miR-556 binding.	5

Citation

Dessen P

GSTM3 (glutathione S-transferase mu 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40770/gstm3-(glutathione-s-transferase-mu-3)