GSTM4 (glutathione S-transferase mu 4)

2003-06-01  

Identity

HGNC
LOCATION
1p13.3
LOCUSID
ALIAS
GSTM4-4,GTM4
FUSION GENES

Other Information

Locus ID:

NCBI: 2948
MIM: 138333
HGNC: 4636
Ensembl: ENSG00000168765

Variants:

dbSNP: 2948
ClinVar: 2948
TCGA: ENSG00000168765
COSMIC: GSTM4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168765ENST00000326729Q03013
ENSG00000168765ENST00000336075A0A0A0MR85
ENSG00000168765ENST00000369833A6NNT0
ENSG00000168765ENST00000369836Q03013
ENSG00000168765ENST00000369836A0A140VKE3
ENSG00000168765ENST00000638994A0A1W2PNX1

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
274664932016Glutathione-S-transferases and Chemotherapy Resistance of Hodgkin's Lymphoma Cell Lines.6
274664932016Glutathione-S-transferases and Chemotherapy Resistance of Hodgkin's Lymphoma Cell Lines.6
198560982010Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1.18
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.25
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.25
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
204854442010Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.13
205298272010The expression of GST isoenzymes and p53 in non-small cell lung cancer.6
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
198560982010Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1.18
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.25
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.25
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
204854442010Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.13
205298272010The expression of GST isoenzymes and p53 in non-small cell lung cancer.6

Citation

Dessen P

GSTM4 (glutathione S-transferase mu 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40771/gstm4-(glutathione-s-transferase-mu-4)