GSTT1 (glutathione S-transferase theta 1)

2003-02-01  

Identity

HGNC
GSTT1
LOCATION
22q11.23
LOCUSID
2952
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2952
MIM: 600436
HGNC: 4641

Variants:

dbSNP: 2952
ClinVar: 2952
COSMIC: GSTT1

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10804imatinibChemicalClinicalAnnotation, VariantAnnotationassociatedPD25188725
PA10832corticosteroidsChemicalVariantAnnotationnot associatedPD26644204
PA130232992bevacizumabChemicalVariantAnnotationnot associatedPD27995989
PA131285527oxaliplatinChemicalVariantAnnotationnot associatedPD27995989
PA162263534OtotoxicityDiseaseClinicalAnnotationassociatedPD17228018, 23274376, 26571237, 26803611
PA162316739Maculopapular ExanthemaDiseaseVariantAnnotationnot associatedPD20036620
PA164712505Antivirals for treatment of HIV infections, combinationsChemicalVariantAnnotationnot associatedPD26667829
PA164712708Drugs For Treatment Of TuberculosisChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014
PA164713176Platinum compoundsChemicalVariantAnnotation, VipGeneambiguousPD26803611
PA164784021ethambutolChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014
PA164925725Toxic liver diseaseDiseaseVariantAnnotationambiguousPD11595069, 18397238, 21753138, 22335459, 24637014, 26667829, 28689274
PA166048678GSTT1 nullHaplotypeVipGeneassociated10801254, 10975610, 11018744, 11447041, 11595069, 11840286, 12172391, 12732844, 14740231, 15882759, 17000715, 17400324, 17438538, 18065725, 19102712, 19143011, 19863340, 20303013, 20385995, 20977336, 21343247, 21436184, 21640195, 21765044, 7954469, 10625170
PA166122986radiotherapyChemicalVariantAnnotationnot associatedPD
PA166179129exacerbation of asthmaDiseaseVariantAnnotationassociated29785881
PA443450AsthmaDiseaseVariantAnnotationassociated29785881
PA443685Uterine Cervical NeoplasmsDiseaseVariantAnnotationnot associatedPD
PA443840DeafnessDiseaseClinicalAnnotation, VariantAnnotationassociatedPD17228018, 23274376, 26571237, 26803611
PA443842DeathDiseaseVariantAnnotationnot associatedPD
PA443937Drug ToxicityDiseaseVariantAnnotationnot associatedPD22845549, 26644204, 27995989
PA444059Epidermal Necrolysis, ToxicDiseaseVariantAnnotationnot associatedPD28689274
PA444109ExanthemaDiseaseVipGeneassociated14740231
PA444442Hepatitis, ToxicDiseaseVariantAnnotationnot associatedPD20036620, 20853551, 22012226
PA444485Hodgkin DiseaseDiseaseVariantAnnotationnot associatedPD23323945
PA444985Multiple MyelomaDiseaseClinicalAnnotationassociatedPD21435719
PA445062NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPD17228018, 23274376, 26571237, 26803611
PA445113NeutropeniaDiseaseVariantAnnotationassociatedPD27168101
PA445204Ovarian NeoplasmsDiseaseVariantAnnotationnot associatedPD26803611
PA445506RecurrenceDiseaseVariantAnnotationnot associatedPD
PA445738Stevens-Johnson SyndromeDiseaseVariantAnnotationnot associatedPD28689274
PA445742Stomach NeoplasmsDiseaseVariantAnnotationnot associatedPD27995989
PA445828Testicular NeoplasmsDiseaseVariantAnnotationnot associatedPD17228018
PA445941TuberculosisDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseVariantAnnotationnot associatedPD26644204
PA446171Leukemia, Myelogenous, Chronic, BCR-ABL PositiveDiseaseClinicalAnnotation, VariantAnnotationassociatedPD25188725
PA447230HIVDiseaseVariantAnnotationnot associatedPD26667829, 28689274
PA448406amoxicillinChemicalVipGeneassociated
PA448515azathioprineChemicalMultilinkAnnotationnot associated23787247
PA448645bleomycinChemicalVariantAnnotationnot associatedPD23323945
PA448771capecitabineChemicalVariantAnnotationnot associatedPD27995989
PA448803carboplatinChemicalVipGeneassociated
PA449014cisplatinChemicalClinicalAnnotation, VariantAnnotation, VipGeneambiguousPD17228018, 23274376, 26571237, 26803611, 27995989
PA449061clozapineChemicalClinicalAnnotation, VariantAnnotationassociatedPD27168101
PA449197dacarbazineChemicalVariantAnnotationnot associatedPD23323945
PA449383docetaxelChemicalVariantAnnotationnot associatedPD27995989
PA449412doxorubicinChemicalVariantAnnotationnot associatedPD23323945
PA449476epirubicinChemicalVariantAnnotationnot associatedPD27995989
PA449552etoposideChemicalVipGeneassociated
PA450112isoniazidChemicalClinicalAnnotation, VariantAnnotation, VipGeneambiguousPKPD11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014
PA450616nevirapineChemicalVariantAnnotationnot associatedPD28689274
PA450761paclitaxelChemicalVariantAnnotationnot associatedPD26803611
PA451182pyrazinamideChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014
PA451250rifampinChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014
PA451512streptomycinChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014
PA451644thalidomideChemicalClinicalAnnotationassociatedPD21435719
PA451743trastuzumabChemicalVariantAnnotationnot associatedPD27995989
PA451799troglitazoneChemicalVipGeneassociated12732844
PA451846valproic acidChemicalVariantAnnotationnot associatedPD
PA451877vinblastineChemicalVariantAnnotationnot associatedPD23323945
PA452604xenobioticsChemicalVipGeneassociated9285043, 9851677, 11317340
PA452621antineoplastic agentsChemicalVariantAnnotationnot associatedPD26644204

References

Pubmed IDYearTitleCitations
381780552024Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children.0
384190252024Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study.0
384628642024Association of Oral Submucous Fibrosis Risk with GSTM1 and GSTT1 Gene Polymorphisms.0
385183932024Combined genetic polymorphisms of the GSTT1 and NRF2 genes increase susceptibility to cisplatin-induced ototoxicity: A preliminary study.0
381780552024Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children.0
384190252024Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study.0
384628642024Association of Oral Submucous Fibrosis Risk with GSTM1 and GSTT1 Gene Polymorphisms.0
385183932024Combined genetic polymorphisms of the GSTT1 and NRF2 genes increase susceptibility to cisplatin-induced ototoxicity: A preliminary study.0
363051312023Impact of GSTT1 and GSTM1 Polymorphisms in the Susceptibility to Philadelphia Negative Chronic Myeloid Leukaemia.0
367032052023Air pollution associated acute respiratory inflammation and modification by GSTM1 and GSTT1 gene polymorphisms: a panel study of healthy undergraduates.2
368333822023Association of GSTTI, M1 and Polymorphism in GSTPI with Chronic Periodontal Disease in a Pakistani Population.1
369637352023Association of NAT2, GSTT1, and GSTM1 gene polymorphisms withprostate cancer risk in Bangladeshi population.0
370548332023Mixed exposure effect of seminal metals on semen quality, mediation of total antioxidant capacity, and moderation of GSTM1/GSTT1 gene deletion in Chinese reproductive-aged men.1
371130882023Absence of GSTT1 and polymorphisms in GSTP1 and TP53 are associated with the incidence of acne vulgaris.2
373267512023Progonostic effect of GSTM1/GSTT1 polymorphism in determining cardiovascular diseases risk among type 2 diabetes patients in South Indian population.0

Citation

Dessen P

GSTT1 (glutathione S-transferase theta 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40774/gstt1-(glutathione-s-transferase-theta-1)