GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene))

2003-06-01  

Identity

HGNC
GSTT2
LOCATION
22q11.23
LOCUSID
2953
ALIAS
-

Other Information

Locus ID:

NCBI: 2953
MIM: 600437
HGNC: 4642
Ensembl: ENSG00000099984

Variants:

dbSNP: 2953
ClinVar: 2953
TCGA: ENSG00000099984
COSMIC: GSTT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099984ENST00000621118A0A087WY67

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

References

Pubmed IDYearTitleCitations
347581582022Proanthocyanidins mitigate bile acid-induced changes in GSTT2 levels in a panel of racially diverse patient-derived primary esophageal cell cultures.3
347581582022Proanthocyanidins mitigate bile acid-induced changes in GSTT2 levels in a panel of racially diverse patient-derived primary esophageal cell cultures.3
305787822019Constitutively Higher Level of GSTT2 in Esophageal Tissues From African Americans Protects Cells Against DNA Damage.12
305787822019Constitutively Higher Level of GSTT2 in Esophageal Tissues From African Americans Protects Cells Against DNA Damage.12
213499092011Glutathione S-transferase copy number variation alters lung gene expression.8
215981792011Impact of polyphenol metabolites produced by colonic microbiota on expression of COX-2 and GSTT2 in human colon cells (LT97).25
213499092011Glutathione S-transferase copy number variation alters lung gene expression.8
215981792011Impact of polyphenol metabolites produced by colonic microbiota on expression of COX-2 and GSTT2 in human colon cells (LT97).25
195289632010Association of common copy number variants at the glutathione S-transferase genes and rare novel genomic changes with schizophrenia.39
195289632010Association of common copy number variants at the glutathione S-transferase genes and rare novel genomic changes with schizophrenia.39
195827852010Methods for detecting interactions between genetic polymorphisms and prenatal environment exposure with a mother-child design.3
198607432010Effect of gene-environment Interactions on mental development in African American, Dominican, and Caucasian mothers and newborns.14
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.25
204378502010Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract in northern Italy.13
195289632010Association of common copy number variants at the glutathione S-transferase genes and rare novel genomic changes with schizophrenia.39

Citation

Dessen P

GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene))

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40775/gstt2-(glutathione-s-transferase-theta-2-(gene-pseudogene))