GTSE1 (G2 and S-phase expressed 1)

2003-02-01 Affiliation

Identity

HGNC

GTSE1

LOCATION

22q13.31

LOCUSID

51512

ALIAS

B99

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51512
MIM: 607477
HGNC: 13698
Ensembl: ENSG00000075218

Variants:

dbSNP: 51512
ClinVar: 51512
TCGA: ENSG00000075218
COSMIC: GTSE1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000075218	ENST00000454366	Q9NYZ3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
p53 signaling pathway	KEGG	ko04115
p53 signaling pathway	KEGG	hsa04115
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle Checkpoints	REACTOME	R-HSA-69620
G2/M Checkpoints	REACTOME	R-HSA-69481
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G2-G2/M phases	REACTOME	R-HSA-453274
G2/M Transition	REACTOME	R-HSA-69275
The role of GTSE1 in G2/M progression after G2 checkpoint	REACTOME	R-HSA-8852276

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20577264	2010	Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery.	45
12750368	2003	The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function.	28
14707141	2004	hGTSE-1 expression stimulates cytoplasmic localization of p53.	24
23236459	2012	GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration.	24
26209226	2015	GTSE1 expression represses apoptotic signaling and confers cisplatin resistance in gastric cancer cells.	16
20800603	2010	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	12
27881713	2016	GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK.	12
20018861	2010	Human GTSE-1 regulates p21(CIP1/WAF1) stability conferring resistance to paclitaxel treatment.	11
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11

Citation

Dessen P

GTSE1 (G2 and S-phase expressed 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40782/gtse1-(g2-and-s-phase-expressed-1)